Evidence map›Paper›PMID 32760080›Full record

Observational studyPloS one2020

Association of acute myocardial infarction with influenza: A nationwide observational study.

Moman A Mohammad, Johan Tham, Sasha Koul, Rebecca Rylance, Cecilia Bergh, David Erlinge, Ole Fröbert

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Moman A MohammadDepartment of Cardiology, Clinical Sciences Lund University, Lund, Sweden.ORCID 0000-0003-4242-9801
Johan ThamInfectious Diseases Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Sasha KoulDepartment of Cardiology, Clinical Sciences Lund University, Lund, Sweden.
Rebecca RylanceDepartment of Cardiology, Clinical Sciences Lund University, Lund, Sweden.
Cecilia BerghClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
David ErlingeDepartment of Cardiology, Clinical Sciences Lund University, Lund, Sweden.
Ole FröbertDepartment of Cardiology, Faculty of Medicine and Health; Örebro University, Örebro, Sweden.
Lund University · SEÖrebro University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInfluenza may precipitate cardiovascular disease, but influenza typically peaks in winter, coinciding with other triggers of myocardial infarction (MI) such as low air temperature, high wind velocity, low atmospheric pressure, and short sunshine duration.

objectiveWe aimed to determine the relationship of week-to-week variation in influenza cases and acute MI, controlling for meteorological factors in a nationwide population.

methodsWeekly laboratory-confirmed influenza case reports were obtained from the Public Health Agency of Sweden from 2009 to 2016 and merged with the nationwide SWEDEHEART MI registry. Weekly incidence of MI was studied with regard to number of influenza cases stratified into tertiles of 0-16, 17-164, and >164 cases/week. Incidence rate ratios (IRR) were calculated using a count regression model for each category and compared to a non-influenza period as reference, controlling for air temperature, atmospheric pressure, wind velocity, and sunshine duration.

resultsA total of 133562 MI events was reported to the registry during the study period. Weeks with influenza cases were associated with higher incidence of MI than those without in unadjusted analysis for overall MI, ST-elevation MI and non ST-elevation MI independently. During the influenza season, weeks with 0-16 reported cases/week were not associated with MI incidence after adjusting for weather parameters, adjusted IRR for MI was 1.03 (95% CI 1.00-1.06, P = 0.09). However, weeks with more cases reported were associated with MI incidence: 17-163 reported cases/week, adjusted IRR = 1.05 (95% CI 1.02-1.08, P = 0.003); and for ≥164 cases/week, the IRR = 1.06 (95% CI 1.02-1.09, P = 0.002). Results were consistent across a large range of subgroups.

conclusionsIn this nationwide observational study, we found an association of incidence of MI with incidence of influenza cases beyond what could be explained by meteorological factors.

Indexed as

Acute DiseaseAgedAged, 80 and overDatabases, FactualFemaleHumansIncidenceInfluenza, HumanMaleMiddle AgedMyocardial InfarctionRegistriesST Elevation Myocardial InfarctionSweden

Identifiers

PMID32760080
PMCPMC7410234
OpenAlexW3047994980

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.