ArticleCommunications biology2020
The rare sugar D-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- A comprehensive review of new pesticides developed between 2015 and 2025.Journal of pesticide science · 2026Article
- Elucidating the Mechanistic Role of Exogenous Melatonin in Salt Stress Tolerance of Maize (Plants (Basel, Switzerland) · 2025Article
- α-Selective Glycosidation of the Rare Sugar d-Tagatofuranose and the Synthesis of α-d-Tagatofuranosylceramide.International journal of molecular sciences · 2025Article
- Photocatalytic syntheses and evaluation of biological activities of rare disaccharides, 3-O-α-D-glucopyranosyl-D-arabinose.Scientific reports · 2025Article
- Systematic synthesis of rare sugars and stereospecific conversion via photocatalysis.Scientific reports · 2025Article
- Article
- Efficacy of L-arabinose in managing cucumber Fusarium wilt and the underlying mechanism of action.Pest management science · 2025Article
- Construction of a multienzyme cascade reaction system and its application in D-tagatose biosynthesis.AMB Express · 2025Article
- Metabolomics-based study on the effect of low-voltage electrostatic field treatment on the storage quality of postharvest square bamboo shoots.Food chemistry: X · 2025Article
- Metabolic profiles in drought-tolerant wheat with enhanced abscisic acid sensitivity.PloS one · 2024Article
- The Relationship between the Sugar Preference of Bacterial Pathogens and Virulence on Plants.The plant pathology journal · 2023Review
- Towards Marker-Assisted Breeding for Black Rot Bunch Resistance: Identification of a Major QTL in the Grapevine Cultivar 'Merzling'.International journal of molecular sciences · 2023Article
- The Amount of the Rare Sugar Tagatose on Tomato Leaves Decreases after Spray Application under Greenhouse Conditions.Plants (Basel, Switzerland) · 2022Article
- Root Transcriptional and Metabolic Dynamics Induced by the Plant Growth Promoting Rhizobacterium (PGPR)Plants (Basel, Switzerland) · 2022Article
- D-Tagatose-Based Product Triggers Sweet Immunity and Resistance of Grapevine to Downy Mildew, but Not to Gray Mold Disease.Plants (Basel, Switzerland) · 2022Article
- Combining Proteomics and Metabolomics to Analyze the Effects of Spaceflight on Rice Progeny.Frontiers in plant science · 2022Article
- Rare Sugars: Recent Advances and Their Potential Role in Sustainable Crop Protection.Molecules (Basel, Switzerland) · 2021Review
- The Differential Growth Inhibition ofFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rare sugar D-tagatose is a safe natural product used as a commercial food ingredient. Here, we show that D-tagatose controls a wide range of plant diseases and focus on downy mildews to analyze its mode of action. It likely acts directly on the pathogen, rather than as a plant defense activator. Synthesis of mannan and related products of D-mannose metabolism are essential for development of fungi and oomycetes; D-tagatose inhibits the first step of mannose metabolism, the phosphorylation of D-fructose to D-fructose 6-phosphate by fructokinase, and also produces D-tagatose 6-phosphate. D-Tagatose 6-phosphate sequentially inhibits phosphomannose isomerase, causing a reduction in D-glucose 6-phosphate and D-fructose 6-phosphate, common substrates for glycolysis, and in D-mannose 6-phosphate, needed to synthesize mannan and related products. These chain-inhibitory effects on metabolic steps are significant enough to block initial infection and structural development needed for reproduction such as conidiophore and conidiospore formation of downy mildew.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.