Evidence map›Paper›PMID 32759765›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations.

J Daniel Martínez, Angela S Infantino, Pablo Valverde, Tammo Diercks, Sandra Delgado, Niels-Christian Reichardt, Ana Ardá, Francisco Javier Cañada, Stefan Oscarson, Jesús Jiménez-Barbero

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Fluorinated ManJournal of the American Chemical Society · 2023
    Article
  4. Fluorine-Directed Automated Mannoside Assembly.Angewandte Chemie (International ed. in English) · 2023
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

J Daniel MartínezCIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology park, Building 800, 48160 Derio, Spain.
Angela S InfantinoCentre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
Pablo ValverdeCIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology park, Building 800, 48160 Derio, Spain.
Tammo DiercksCIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology park, Building 800, 48160 Derio, Spain.
Sandra DelgadoCIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology park, Building 800, 48160 Derio, Spain.
Niels-Christian ReichardtCIC biomaGUNE, Basque Research Technology Alliance, BRTA, Miramon Park, 20014 San Sebastian, Spain.
Ana ArdáCIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology park, Building 800, 48160 Derio, Spain.
Francisco Javier CañadaCentro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Stefan OscarsonCentre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
Jesús Jiménez-BarberoCIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology park, Building 800, 48160 Derio, Spain.
CIC bioGUNE · ESUniversity College Dublin · IECentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESCIC biomaGUNE · ESIkerbasque · ES

Funding

Agencia Estatal de Investigación CTQ2015-68756-RAgencia Estatal de Investigación RTI2018-094751-B-C21 and C-22Agencia Estatal de Investigación SEV-2016-0644European Research Council 788143Science Foundation Ireland 13/IA/1959
6 · The paper itself

Abstract

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein-glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein-ligand complexes. We herein present a new methodology based on the synergic combination of experimental

Indexed as

CORCEMADC-SIGNfluorinated carbohydratesglycansglycomimeticslectinMD simulationsmolecular recognitionNMRSTD-NMR

Identifiers

PMID32759765
PMCPMC7463913
OpenAlexW3047010123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.