Evidence map›Paper›PMID 32759740›Full record

ArticleInternational journal of molecular sciences2020

RAP-011 Rescues the Disease Phenotype in a Cellular Model of Congenital Dyserythropoietic Anemia Type II by Inhibiting the SMAD2-3 Pathway.

Gianluca De Rosa, Immacolata Andolfo, Roberta Marra, Francesco Manna, Barbara Eleni Rosato, Achille Iolascon, Roberta Russo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. New Cases and Mutations inInternational journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gianluca De RosaDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-5504-0988
Immacolata AndolfoDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.
Roberta MarraDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.
Francesco MannaCeinge Biotecnologie Avanzate, 80145 Naples, Italy.
Barbara Eleni RosatoDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.
Achille IolasconDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-9558-0356
Roberta RussoDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-3624-7721
Ceinge Biotecnologie Avanzate (Italy) · IT

Funding

European Hematology Association (EHA) Junior Research Grant 2018, 3978026Programme STAR, UniNA and Compagnia di San Paolo -Spanish foundation "Ramón Areces" CIVP18A1857 - CoDysAn project
6 · The paper itself

Abstract

Congenital dyserythropoietic anemia type II (CDA II) is a hypo-productive anemia defined by ineffective erythropoiesis through maturation arrest of erythroid precursors. CDA II is an autosomal recessive disorder due to loss-of-function mutations in

Indexed as

Anemia, Dyserythropoietic, CongenitalBone Morphogenetic ProteinsErythroid Precursor CellsErythropoiesisFemaleGATA1 Transcription FactorGrowth Differentiation FactorsHumansK562 CellsMutationPhenotypeRecombinant Fusion ProteinsSmad2 ProteinSmad3 ProteinVesicular Transport ProteinsActRIIA-mIgG2aFc fusion proteinBone Morphogenetic ProteinsGATA1 protein, humanGATA1 Transcription FactorGDF11 protein, humanGrowth Differentiation FactorsRecombinant Fusion ProteinsSEC23B protein, humanSmad2 ProteinSMAD2 protein, humanSmad3 ProteinSMAD3 protein, humansotaterceptVesicular Transport Proteinsactivin receptor II ligand trapcongenital dyserythropoietic anemia type IIin vitro drug treatment

Identifiers

PMID32759740
PMCPMC7432210
OpenAlexW3047354148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.