Evidence map›Paper›PMID 32759307›Full record

ArticleThe Journal of biological chemistry2020

miR-26a mediates LC-PUFA biosynthesis by targeting the Lxrα-Srebp1 pathway in the marine teleost

Cuiying Chen, Shuqi Wang, Yu Hu, Mei Zhang, Xianda He, Cuihong You, Xiaobo Wen, Óscar Monroig, Douglas R Tocher, Yuanyou Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Cuiying ChenGuangdong Provincial Key Laboratory of Marine Biotechnology and Research Center for Nutrition, Feed and Healthy Breeding of Aquatic Animals of Guangdong Province, Shantou University, Shantou, China.
Shuqi WangGuangdong Provincial Key Laboratory of Marine Biotechnology and Research Center for Nutrition, Feed and Healthy Breeding of Aquatic Animals of Guangdong Province, Shantou University, Shantou, China.
Yu HuGuangdong Provincial Key Laboratory of Marine Biotechnology and Research Center for Nutrition, Feed and Healthy Breeding of Aquatic Animals of Guangdong Province, Shantou University, Shantou, China.
Mei ZhangGuangdong Provincial Key Laboratory of Marine Biotechnology and Research Center for Nutrition, Feed and Healthy Breeding of Aquatic Animals of Guangdong Province, Shantou University, Shantou, China.
Xianda HeGuangdong Provincial Key Laboratory of Marine Biotechnology and Research Center for Nutrition, Feed and Healthy Breeding of Aquatic Animals of Guangdong Province, Shantou University, Shantou, China.
Cuihong YouGuangdong Provincial Key Laboratory of Marine Biotechnology and Research Center for Nutrition, Feed and Healthy Breeding of Aquatic Animals of Guangdong Province, Shantou University, Shantou, China.
Xiaobo WenCollege of Marine Sciences of South China Agricultural University and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Óscar MonroigInstituto de Acuicultura Torre de la Sal-Consejo Superior de Investigaciones Científicas, Castellón, Spain.
Douglas R TocherInstitute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling, Scotland, United Kingdom.
Yuanyou LiCollege of Marine Sciences of South China Agricultural University and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China. Electronic address: yyli16@scau.edu.cn.
Shantou University · CNSouth China Agricultural University · CNConsejo Superior de Investigaciones Científicas · ESUniversity of Stirling · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs have been recently shown to be important regulators of lipid metabolism. However, the mechanisms of microRNA-mediated regulation of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis in vertebrates remain largely unknown. Herein, we for the first time addressed the role of miR-26a in LC-PUFA biosynthesis in the marine rabbitfish

Indexed as

AnimalsCell LineFatty Acids, UnsaturatedFishesFish ProteinsHepatocytesLiver X ReceptorsMicroRNAsSterol Regulatory Element Binding Protein 1Fatty Acids, UnsaturatedFish ProteinsLiver X ReceptorsMicroRNAsSterol Regulatory Element Binding Protein 1biosynthesisfatty acidfatty acid metabolismgene regulationLC-PUFALxrαmicroRNA (miRNA)miR-26aSiganus canaliculatusSrebp1

Identifiers

PMID32759307
PMCPMC7535907
OpenAlexW3047202792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.