Evidence map›Paper›PMID 32759295›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

TCR Signal Strength and Antigen Affinity Regulate CD8

Sabrina Solouki, Weishan Huang, Jessica Elmore, Candice Limper, Fei Huang, Avery August

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 75 citations in OpenAlex.

  1. Interferon regulatory factors orchestrate CD8International journal of molecular medicine · 2026
    Review
  2. Article
  3. DUSP4 promotes anti-tumor CD8Nature communications · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Atomistic TCR-ligand interactions instruct memory T-cell differentiation.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Zeaxanthin augments CD8Cell reports. Medicine · 2025
    Article
  13. CCR2Cellular & molecular immunology · 2025
    Article
  14. Review
  15. Engineering resilient CAR T cells for immunosuppressive environment.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sabrina SoloukiDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853; and.
Weishan HuangDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853; and.ORCID 0000-0002-1330-1131
Jessica ElmoreDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853; and.ORCID 0000-0002-4360-0378
Candice LimperDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853; and.ORCID 0000-0001-6945-069X
Fei HuangDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853; and.
Avery AugustDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853; and averyaugust@cornell.edu.ORCID 0000-0003-4968-3415
Cornell University · USLouisiana State University · US

Funding

The role of adipocyte-driven inflammation and leptin pathway in pulmonary viral infections caused by SARS-CoV-2 and influenza A virusesP20GM130555 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Stephania A Cormier, TAMMY R DUGAS · 2019 to 2026
$19.9M
Small RNA Pathways in Mammalian GametogenesisP50HD076210 · NICHD · CORNELL UNIVERSITY · PI COHEN, PAULA ELAINE · 2014 to 2018
$7.4M
Activation of the Ah receptor and epithelial integrityR35ES028244 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PERDEW, GARY H. · 2017 to 2024
$6.2M
Regulation of IL10 production in CD8+ T cells during Flu infection by tyrosine kinase ItkR01AI138570 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2018 to 2022
$2.1M
Itk mediated tuning of CD8+ memory T cell developmentR01AI120701 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2016 to 2019
$1.5M
Immuno-Engineering: Integrated Engineering and Immunology TrainingT32EB023860 · NIBIB · CORNELL UNIVERSITY · PI AUGUST, AVERY, PUTNAM, DAVID A · 2018 to 2022
$933k
A novel murine model of allergic airway inflammation.R21AI138497 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY, HUANG, WEISHAN · 2018 to 2019
$443k
Itk signaling and Type 1 regulatory T cell differentiation and function in allergic airway inflammationR21AI129422 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY, HUANG, WEISHAN · 2018 to 2019
$431k
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI120701NIAID NIH HHS R01 AI138570NIAID NIH HHS R21 AI129422NIAID NIH HHS R21 AI138497NIBIB NIH HHS T32 EB023860NICHD NIH HHS P50 HD076210NIEHS NIH HHS R35 ES028244NIGMS NIH HHS P20 GM130555
6 · The paper itself

Abstract

CD8

Indexed as

AnimalsAntigensCD8-Positive T-LymphocytesCell DifferentiationCytokinesFemaleImmunologic MemoryInflammationMaleMiceMice, Inbred C57BLProtein-Tyrosine KinasesReceptors, Antigen, T-CellSignal TransductionAntigensCytokinesProtein-Tyrosine KinasesReceptors, Antigen, T-Cell

Identifiers

PMID32759295
PMCPMC8104072
OpenAlexW3047047153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.