ArticleScience translational medicine2020
Estrogen receptor α controls metabolism in white and brown adipocytes by regulating
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 102 citations in OpenAlex.
- Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- 17α-Estradiol: A mildly feminizing estrogen with sex-specific metabolic and lifespan benefits.Ageing research reviews · 2026Review
- Article
- Gdf15 expression in thermogenic adipocytes regulates diet-induced weight gain in a sex-dependent manner.Molecular medicine (Cambridge, Mass.) · 2026Article
- Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway.Science advances · 2026Article
- Targeted Disruption of Selenocysteine Lyase in Brown Adipocytes Controls Glutathione Peroxidase 1 and 4 Expression in Males.Biological trace element research · 2026Article
- Article
- Estradiol treatment induces both shared and unique gene regulation and networks in adipose cell types of gonadectomized obese XX and XY mice.Biology of sex differences · 2026Article
- Context-dependent roles of sex hormone signaling in controlling visceral adipose tissue Treg heterogeneity and clonal expansion.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Integrated chromatin and transcriptomic profiling reveals sex-specific mechanisms of gene regulation in hepatic nutrient responses.PLoS biology · 2026Article
- The role of extracellular vesicles in the context of (inter-)cellular communication contributing to adipose tissue dysfunction in lipedema.Frontiers in cell and developmental biology · 2026Review
- Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology.Biology of sex differences · 2025Review
- A Mouse Model of Lipoatrophy Reveals Relationships Between Beige Fat Appearance and Female Fertility.Endocrinology · 2025Article
- Epigenetic programming of estrogen receptor in adipocytes by high-fat diet regulates obesity-induced inflammation.JCI insight · 2025Article
- Sex and Gender Differences in Obesity: Biological, Sociocultural, and Clinical Perspectives.The world journal of men's health · 2025Review
- Adipose Tissue Estrogen Receptor-Alpha Overexpression Ameliorates High-Fat Diet-Induced Adipose Tissue Inflammation.Journal of the Endocrine Society · 2025Article
- Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- Metabolic Messengers: oestradiol.Nature metabolism · 2025Review
- Loss of ovarian function prevents exercise-induced activation of hepatic mitophagic flux.American journal of physiology. Endocrinology and metabolism · 2025Article
- Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males.Cell reports. Medicine · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
31 authors at 8 institutions in 4 countries.
Zhenqi ZhouDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-6560-9704
Timothy M MooreDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Brian G DrewDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Vicent RibasDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-3380-2256
Jonathan WanagatDivision of Geriatrics, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Mete CivelekDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-8141-0284
Mayuko SegawaDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-5680-9576
Dane M WolfDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-0811-1114
Frode NorheimDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Marcus M SeldinDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-8026-4759
Alexander R StrumwasserDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Kate A WhitneyDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Ellen LesterDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-1904-6407
Britany R ReddishDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-9402-9757
Laurent VergnesDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Karen ReueDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Prashant RajbhandariDepartment of Pathology and Laboratory Medicine and the Howard Hughes Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Peter TontonozDepartment of Pathology and Laboratory Medicine and the Howard Hughes Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Jason LeeDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-2590-2011
Sushil K MahataVA San Diego Healthcare System, San Diego, CA 92161, USA.ORCID 0000-0002-9154-0787
Sylvia C HewittReceptor Biology Section, NIEHS, NIH, Research Triangle Park, NC 27709, USA.ORCID 0000-0001-7713-0805
Orian ShirihaiDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Craig GastonburyDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE17EH, UK.ORCID 0000-0001-5542-2225
Kerrin S SmallDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE17EH, UK.ORCID 0000-0003-4566-0005
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Jorgen JensenDepartment of Physical Performance, Norwegian School of Sport Science, Oslo 0806, Norway.ORCID 0000-0001-5851-220X
Sindre LeeUniversity Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo 0316, Norway.ORCID 0000-0002-0670-7555
Christian A DrevonUniversity Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo 0316, Norway.ORCID 0000-0002-7216-2784
Kenneth S KorachReceptor Biology Section, NIEHS, NIH, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-7765-418X
Aldons J LusisDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Andrea L HevenerDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA. ahevener@mednet.ucla.edu.ORCID 0000-0003-1508-4377
University of California, Los Angeles · USHoward Hughes Medical Institute · USKing's College London · GBResearch Triangle Park Foundation · USUniversity of Oslo · NONorwegian School of Sport Sciences · NOUniversity of California San Diego · USUniversity of Eastern Finland · FI
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2MSystems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 1985 to 2019
$50.2MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MChemical Receptor Interactions In Reproduction And Hormonal ToxicityZIAES070065 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI KORACH, KENNETH S · 2009 to 2019
$29.6MTraining and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1MTrafficking of catecholamine storage vesicle proteinsP01HL058120 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZIEGLER, MICHAEL G. · 1999 to 2009
$18.5MUCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8MEXPANSION OF NURSA TRANSCRIPTOMINE ANNOTATIONU24DK097748 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI EVANS, RONALD M, MCKENNA, NEIL · 2012 to 2017
$9.2MSex Differences in the Metabolic SyndromeU54DK120342 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2018 to 2022
$7.6MMechanisms controlling skeletal muscle mitochondrial function and metabolic healthR01DK109724 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEVENER, ANDREA L · 2016 to 2020
$2.4MBLRD VA I01 BX000323BLRD VA I01 BX003934BLRD VA IS1 BX005048Intramural NIH HHS ZIA ES070065Medical Research Council MR/L01999X/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NHLBI NIH HHS P01 HL028481NHLBI NIH HHS P01 HL030568NHLBI NIH HHS P01 HL058120NIAMS NIH HHS U54 AR052646NIA NIH HHS P30 AG028748NIDA NIH HHS R01 DA011311NIDA NIH HHS R29 DA011311NIDDK NIH HHS F31 DK108657NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK099618NIDDK NIH HHS R01 DK109724NIDDK NIH HHS U24 DK097748NIDDK NIH HHS U54 DK120342
Abstract
Obesity is heightened during aging, and although the estrogen receptor α (ERα) has been implicated in the prevention of obesity, its molecular actions in adipocytes remain inadequately understood. Here, we show that adipose tissue
Indexed as
Adipocytes, BrownEstrogen Receptor alphaAdipocytes, WhiteAdipose Tissue, BrownAnimalsFemaleMiceMitochondriaMitochondrial ProteinsThermogenesisUncoupling Protein 1Estrogen Receptor alphaMitochondrial ProteinsUncoupling Protein 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.