Evidence map›Paper›PMID 32759249›Full record

ArticleBMJ open2020

Clopidogrel preventive effect based on cytochrome P450 2C19 genotype in ischaemic stroke: protocol for multicentre observational study.

Tae-Jin Song, Jinkwon Kim, Sang Won Han, Young Dae Kim, Jong Yun Lee, Seong Hwan Ahn, Hye Sun Lee, Yo Han Jung, Kyung-Yul Lee

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04072705 (A Multicenter Prospective observationaL Study to evAluate the effecT of Clopidogrel on the prEvention of Major vascuLar Events According to the gEnotype of Cytochrome P450 2C19 in Ischemic Stroke paTients; PLATELET Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04072705 completednot on this map

A Multicenter Prospective observationaL Study to evAluate the effecT of Clopidogrel on the prEvention of Major vascuLar Events According to the gEnotype of Cytochrome P450 2C19 in Ischemic Stroke paTients; PLATELET Study

TypeobservationalSponsorGangnam Severance HospitalRan2019 to 2023Enrolled2,927ConditionsAcute Ischemic StrokeArmsGeneral principles of care and judgement of researcher
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Tae-Jin SongDepartment of Neurology, Seoul Hospital, College of Medicine, Ewha Womans University, Seoul, South Korea.ORCID 0000-0002-9937-762X
Jinkwon KimDepartment of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Sang Won HanDepartment of Neurology, Inje University Sanggye Paik Hospital, Seoul, South Korea.
Young Dae KimDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Jong Yun LeeDepartment of Neurology, National Medical Center, Seoul, South Korea.
Seong Hwan AhnDepartment of Neurology, Chosun University Hospital, Gwangju, South Korea.
Hye Sun LeeBiostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea.
Yo Han JungDepartment of Neurology, Gangnam Severance Hospital, Yonsei University Collegel of Medicine, Seoul, South Korea.
Kyung-Yul LeeDepartment of Neurology, Gangnam Severance Hospital, Yonsei University Collegel of Medicine, Seoul, South Korea kylee@yuhs.ac.ORCID 0000-0001-5585-7739
Yonsei University · KRChosun University Hospital · KREwha Womans University · KRInje University Sanggye Paik Hospital · KRNational Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClopidogrel is an antiplatelet agent that is widely used for the secondary prevention of cardiovascular and cerebrovascular events. The genotype of cytochrome P450 2C19 ( METHODS AND ANALYSIS: This prospective observational multicentre study was designed to determine whether composite cardiovascular events would differ among patients who had an ischaemic stroke prescribed clopidogrel according to ETHICS AND DISSEMINATION: The Institutional Review Board of Severance Hospital, Yonsei University College of Medicine approved this study (3-2019-0195). We received study approval from the institutional review board of each participating hospital. We plan to disseminate our findings at relevant conferences and meetings and through peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT04072705.

Indexed as

Brain IschemiaIschemic StrokeStrokeClopidogrelCytochrome P-450 CYP2C19GenotypeHumansMulticenter Studies as TopicObservational Studies as TopicPlatelet Aggregation InhibitorsProspective StudiesTiclopidineTreatment OutcomeClopidogrelCytochrome P-450 CYP2C19Platelet Aggregation InhibitorsTiclopidineneurogeneticsneurologystroke

Identifiers

PMID32759249
PMCPMC7409960
OpenAlexW3047332900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.