Evidence map›Paper›PMID 32759209›Full record

ReviewProceedings of the National Academy of Sciences of the United States of America2020

Shedding new light on the generation of the visual chromophore.

Krzysztof Palczewski, Philip D Kiser

Open access · bronzeAbstract readReview
In one paragraph

Review in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
    Review
  9. Loss of the vitamin A receptor RBPR2 in mice disrupts whole-body retinoid homeostasis and the quantitative balance regulating retinylidene protein synthesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  10. Expression of proteins supporting visual function in heterobranch gastropods.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. International journal of molecular sciences · 2024
    Article
  16. Article
  17. Article
  18. Pet Wellness and Vitamin A: A Narrative Overview.Animals : an open access journal from MDPI · 2024
    Review
  19. Review
  20. Cell-cell interaction in the pathogenesis of inherited retinal diseases.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Krzysztof PalczewskiThe Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine School of Medicine, Irvine, CA 92697; kpalczew@uci.edu.ORCID 0000-0002-0788-545X
Philip D KiserThe Department of Physiology & Biophysics, and Chemistry, University of California, Irvine School of Medicine, Irvine, CA 92697.ORCID 0000-0003-1184-9539
University of California, Irvine · US

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
REGULATION OF RHODOPSIN KINASE AND GUANYLATE CYCLASER01EY008061 · NEI · UNIVERSITY OF WASHINGTON · PI PALCZEWSKI, KRZYSZTOF · 1994 to 2014
$9.5M
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
MECHANISMS OF ADAPTATION IN MAMMALIAN CONESR01EY019312 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV · 2009 to 2017
$3.3M
A two-photon ophthalmoscope for human retinal imaging and functional testingU01EY025451 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2015 to 2019
$3.2M
Retinoid cycles and retinal disease treatmentI01BX004939 · VA · VETERANS HEALTH ADMINISTRATION · PI KISER, PHILIP DAVID · 2020 to 2025
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BLRD VA I01 BX004939NEI NIH HHS R01 EY008061NEI NIH HHS R01 EY009339NEI NIH HHS R01 EY019312NEI NIH HHS R24 EY027283NEI NIH HHS U01 EY025451
6 · The paper itself

Abstract

The visual phototransduction cascade begins with a

Indexed as

Vision, OcularAnimalsHumansLightLight Signal TransductionOpsinsRetinal Cone Photoreceptor CellsRetinaldehydeRetinal Pigment EpitheliumOpsinsRetinaldehydechromophoreeyelightretinavision

Identifiers

PMID32759209
PMCPMC7443880
OpenAlexW3047420876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.