SynthesisNeuroImage. Clinical2020
Imaging Alzheimer's genetic risk using diffusion MRI: A systematic review.
Synthesis in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 43 citations in OpenAlex.
- Macro-Micro structural integration for characterizing severity-related structural alterations in mild cognitive impairment.NeuroImage. Clinical · 2026Article
- A spatially resolved genomic-molecular atlas of human white-matter microstructure.medRxiv : the preprint server for health sciences · 2026Article
- Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Integrated imaging and molecular profiling reveals APOE4-associated neurovascular and glial disruptions in young adult mice.Journal of neuroinflammation · 2026Article
- Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.The European journal of neuroscience · 2026Review
- Differences in white matter detected by ex vivo 9.4 T MRI are associated with axonal changes in the R6/1 model of Huntington's disease.Neurobiology of disease · 2026Article
- A relaxation-diffusion MRI dataset of aging mouse brains at 9.4 Tesla.Scientific data · 2025Article
- New insights into translational research in Alzheimer's disease guided by artificial intelligence, computational and systems biology.Acta pharmaceutica Sinica. B · 2025Review
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI.Scientific data · 2025Article
- The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Approximate diffusion tractography from FLAIR MRI and anatomical context using recurrent neural networks.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Biomarker Investigation Using Multiple Brain Measures from MRI Through Explainable Artificial Intelligence in Alzheimer's Disease Classification.Bioengineering (Basel, Switzerland) · 2025Article
- White matter microstructure in mid- to late adulthood is influenced by pathway-stratified polygenic risk for Alzheimer's disease.Frontiers in neuroscience · 2025Article
- Field-of-view extension for brain diffusion MRI via deep generative models.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Deep learning with diffusion MRI as in vivo microscope reveals sex-related differences in human white matter microstructure.Scientific reports · 2024Article
- MRI and Clinical Biomarkers Overlap between Glaucoma and Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Review
- Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges.Acta neuropathologica · 2023Review
- The role of magnetic resonance imaging in the diagnosis and prognosis of dementia.Biomolecules & biomedicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Diffusion magnetic resonance imaging (dMRI) is an imaging technique which probes the random motion of water molecules in tissues and has been widely applied to investigate changes in white matter microstructure in Alzheimer's Disease. This paper aims to systematically review studies that examined the effect of Alzheimer's risk genes on white matter microstructure. We assimilated findings from 37 studies and reviewed their diffusion pre-processing and analysis methods. Most studies estimate the diffusion tensor (DT) and compare derived quantitative measures such as fractional anisotropy and mean diffusivity between groups. Those with increased AD genetic risk are associated with reduced anisotropy and increased diffusivity across the brain, most notably the temporal and frontal lobes, cingulum and corpus callosum. Structural abnormalities are most evident amongst those with established Alzheimer's Disease. Recent studies employ signal representations and analysis frameworks beyond DT MRI but show that dMRI overall lacks specificity to disease pathology. However, as the field advances, these techniques may prove useful in pre-symptomatic diagnosis or staging of Alzheimer's disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.