ArticleMolecular and cellular biology1988
Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 121 citations in OpenAlex.
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- Nonstructural Protein σ1s Is Required for Optimal Reovirus Protein Expression.Journal of virology · 2018Article
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- Conserved structure/function of the orthoreovirus major core proteins.Virus research · 2009Article
- Avian reovirus L2 genome segment sequences and predicted structure/function of the encoded RNA-dependent RNA polymerase protein.Virology journal · 2008Article
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- Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation.Journal of virology · 2005Article
- Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection.Journal of virology · 2003Article
- Reovirus sigma NS protein localizes to inclusions through an association requiring the mu NS amino terminus.Journal of virology · 2003Article
- RNA-binding activity of the rotavirus phosphoprotein NSP5 includes affinity for double-stranded RNA.Journal of virology · 2002Article
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- Sequence analysis of the S3 gene from a turkey reovirus.Virus genes · 2002Article
- Atomic structure of the major capsid protein of rotavirus: implications for the architecture of the virion.The EMBO journal · 2001Article
- Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.Journal of virology · 1999Article
- Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA.The Biochemical journal · 1998Article
- Core protein mu2 is a second determinant of nucleoside triphosphatase activities by reovirus cores.Journal of virology · 1997Article
- Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
By atomic absorption analysis, we determined that the reovirus outer capsid protein sigma 3, which binds double-stranded RNA (dsRNA), is a zinc metalloprotein. Using Northwestern blots and a novel zinc blotting technique, we localized the zinc- and dsRNA-binding activities of sigma 3 to distinct V8 protease-generated fragments. Zinc-binding activity was contained within an amino-terminal fragment that contained a transcription factor IIIA-like zinc-binding sequence, and dsRNA-binding activity was associated with a carboxy-terminal fragment. By these techniques, new zinc- and dsRNA-binding activities were also detected in reovirus core proteins. A sequence similarity was observed between the catalytic site of the picornavirus proteases and the transcription factor IIIA-like zinc-binding site within sigma 3. We suggest that the zinc- and dsRNA-binding activities of sigma 3 may be important for its proposed regulatory effects on viral and host cell transcription and translation.
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