Evidence map›Paper›PMID 32758635›Full record

ReviewPharmacological research2020

COVID-19: Pharmacology and kinetics of viral clearance.

Nicola Farina, Giuseppe A Ramirez, Rebecca De Lorenzo, Luigi Di Filippo, Caterina Conte, Fabio Ciceri, Angelo A Manfredi, Patrizia Rovere-Querini

Open access · greenAbstract readReview
In one paragraph

Review in Pharmacological research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.5field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. A case-crossover analysis of short-term PMCommunications medicine · 2025
    Article
  3. Article
  4. Article
  5. Autoantibodies in hospitalised patients with COVID-19.Clinical & translational immunology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Observational
  13. Clinical features and outcomes of critically ill patients with coronavirus disease 2019 (COVID-19): A multicenter cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nicola FarinaVita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy.
Giuseppe A RamirezVita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy.
Rebecca De LorenzoVita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy.
Luigi Di FilippoVita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy.
Caterina ConteVita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy; Division of Immunology, Transplantation and Infectious Diseases, via Olgettina 60, 20132 Milano, Italy.
Fabio CiceriVita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy; Division of Immunology, Transplantation and Infectious Diseases, via Olgettina 60, 20132 Milano, Italy.
Angelo A ManfrediVita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy; Division of Immunology, Transplantation and Infectious Diseases, via Olgettina 60, 20132 Milano, Italy.
Patrizia Rovere-QueriniVita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy; Division of Immunology, Transplantation and Infectious Diseases, via Olgettina 60, 20132 Milano, Italy. Electronic address: rovere.patrizia@hsr.it.
Vita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. This heterogeneity might reflect the ability of the host immune system to interact with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence. Information on this issue might derive from interventional studies. However, results from high-quality trials are scarce. Here we evaluate the level of evidence of available published interventional studies, with a focus on randomised controlled trials and the efficacy of therapies on clinical outcomes. Moreover, we present data on a large cohort of well-characterized patients hospitalized at a single University Hospital in Milano (Italy), correlating viral clearance with clinical and biochemical features of patients.

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2Antiviral AgentsCOVID-19HumansViral LoadAntiviral AgentsCOVID-19PharmacologySARS-CoV-2Viral clearance kinetics

Identifiers

PMID32758635
PMCPMC7834389
OpenAlexW3046747384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.