Evidence map›Paper›PMID 32758418›Full record

ArticleCell2020

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.

Sho Kitamoto, Hiroko Nagao-Kitamoto, Yizu Jiao, Merritt G Gillilland, Atsushi Hayashi, Jin Imai, Kohei Sugihara, Mao Miyoshi, Jennifer C Brazil, Peter Kuffa and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 419 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
419citing papers in PubMed, 10 pooled it
26.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

419 citing papers in PubMed, 10 syntheses or guidelines pooled it, 631 citations in OpenAlex.

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  20. Exacerbation of inflammatory bone loss in TET2-driven clonal hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article

359 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Sho KitamotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Hiroko Nagao-KitamotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Yizu JiaoDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Merritt G GillillandDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Atsushi HayashiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Research Laboratory, Miyarisan Pharmaceutical Co., Ltd., Tokyo, Japan.
Jin ImaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Kohei SugiharaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Mao MiyoshiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jennifer C BrazilDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Peter KuffaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Brett D HillDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
Syed M RizviDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
Fei WenDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
Shrinivas BishuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Naohiro InoharaDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Kathryn A EatonDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Asma NusratDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Yu L LeiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
William V GiannobileDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Nobuhiko KamadaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address: nkamada@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
Restoring the Immunogenicity of Head and Neck CancerR01DE026728 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yu Leo Lei, James J. Moon · 2018 to 2026
$4.3M
Robust Immuno-prevention Strategies for High-Risk Oral Epithelial DysplasiaU01DE029255 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRENNER, JOHN CHADWICK, LEI, YU LEO · 2019 to 2021
$4.2M
The role of IL-1ß-inducing pathobionts in the pathogenesis of Crohn’s diseaseR01DK108901 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nobuhiko Kamada · 2017 to 2026
$3.8M
The link between oral bacteria and gut diseaseR01DK119219 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAMADA, NOBUHIKO · 2019 to 2022
$1.6M
Cytometry by Time of Fight (CyTOF) for High-speed Single-cell AnalysisS10OD020053 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEN, FEI · 2016 to 2016
$600k
Periodontitis and extra-oral mucosal inflammationR21AI142047 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAMADA, NOBUHIKO · 2019 to 2020
$429k
NCATS NIH HHS UL1 TR002240NIAID NIH HHS R21 AI142047NIDCR NIH HHS R01 DE026728NIDCR NIH HHS U01 DE029255NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK108901NIDDK NIH HHS R01 DK119219NIH HHS S10 OD020053
6 · The paper itself

Abstract

The precise mechanism by which oral infection contributes to the pathogenesis of extra-oral diseases remains unclear. Here, we report that periodontal inflammation exacerbates gut inflammation in vivo. Periodontitis leads to expansion of oral pathobionts, including Klebsiella and Enterobacter species, in the oral cavity. Amassed oral pathobionts are ingested and translocate to the gut, where they activate the inflammasome in colonic mononuclear phagocytes, triggering inflammation. In parallel, periodontitis results in generation of oral pathobiont-reactive Th17 cells in the oral cavity. Oral pathobiont-reactive Th17 cells are imprinted with gut tropism and migrate to the inflamed gut. When in the gut, Th17 cells of oral origin can be activated by translocated oral pathobionts and cause development of colitis, but they are not activated by gut-resident microbes. Thus, oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.

Indexed as

Gastrointestinal MicrobiomeAnimalsColitisColonDisease Models, AnimalEnterobacterFemaleInflammasomesInterleukin-10Interleukin-1betaKlebsiellaLeukocytes, MononuclearMaleMiceMice, Inbred C57BLMice, KnockoutInflammasomesInterleukin-10Interleukin-1betacolitisdysbiosisinflammasomeinflammatory bowel diseaseKlebsiellamicrobiotaoral bacteriapathobiontperiodontitisTH17

Identifiers

PMID32758418
PMCPMC7414097
OpenAlexW3035326193

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.