ArticlePsychological medicine2022
The incidence of non-affective psychotic disorders in Chile between 2005 and 2018: results from a national register of over 30 000 cases.
Article in Psychological medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06588270 (Effect of Virtual Reality-based Therapy on Negative Symptoms in People with Schizophrenia), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Virtual Reality-based Therapy on Negative Symptoms in People with Schizophrenia: Study Protocol for a Randomized Controlled Trial
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Defining Urbanicity in the Context of Psychosis Research: A Qualitative Systematic Literature Review.Schizophrenia bulletin · 2025Pooled it
- The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2023Pooled it
- Cost-effectiveness of early intervention in psychosis in Latin America: economic evaluation of Chilean services.BJPsych open · 2026Article
- Searching for people with psychosis in the global south: mapping and establishing a case surveillance system in South Africa (PSYMAP-ZN study).Social psychiatry and psychiatric epidemiology · 2026Article
- Urbanicity, parental social deprivation, and risk of early psychosis in Chile: a national cohort study.Lancet regional health. Americas · 2025Article
- A Critical Overview of Mental Health Policies for the Treatment of Schizophrenia in Chile.Actas espanolas de psiquiatria · 2025Article
- The impact of socioeconomic factors on the incidence and characteristics of first-episode psychosis.Epidemiology and psychiatric sciences · 2025Article
- Universal healthcare coverage for first episode of schizophrenia-spectrum disorders in Chile: analysis of the administrative database.European archives of psychiatry and clinical neuroscience · 2022Article
- Consent, decisional capacity and guardianship in mental health research.Wellcome open research · 2022Article
- Urbanization level and neighborhood deprivation, not COVID-19 case numbers by residence area, are associated with severe psychological distress and new-onset suicidal ideation during the COVID-19 pandemic.Journal of affective disorders · 2021Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundEvidence suggests the incidence of non-affective psychotic disorders (NAPDs) varies across persons and places, but data from the Global South is scarce. We aimed to estimate the treated incidence of NAPD in Chile, and variance by person, place and time.
methodsWe used national register data from Chile including all people, 10-65 years, with the first episode of NAPD (International Classification of Diseases, Tenth Revision: F20-F29) between 1 January 2005 and 29 August 2018. Denominators were estimated from Chilean National Census data. Our main outcome was treated incidence of NAPD and age group, sex, calendar year and regional-level population density, multidimensional poverty and latitude were exposures of interest.
resultsWe identified 32 358 NAPD cases [12 136 (39.5%) women; median age-at-first-contact: 24 years (interquartile range 18-39 years)] during 171.1 million person-years [crude incidence: 18.9 per 100 000 person-years; 95% confidence interval (CI) 18.7-19.1]. Multilevel Poisson regression identified a strong age-sex interaction in incidence, with rates peaking in men (57.6 per 100 000 person-years; 95% CI 56.0-59.2) and women (29.5 per 100 000 person-years; 95% CI 28.4-30.7) between 15 and 19 years old. Rates also decreased (non-linearly) over time for women, but not men. We observed a non-linear association with multidimensional poverty and latitude, with the highest rates in the poorest regions and those immediately south of Santiago; no association with regional population density was observed.
conclusionOur findings inform the aetiology of NAPDs, replicating typical associations with age, sex and multidimensional poverty in a Global South context. The absence of association with population density suggests this risk may be context-dependent.
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