Evidence map›Paper›PMID 32758186›Full record

ArticleBMC ophthalmology2020

Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach.

Erqian Wang, Xinyu Zhao, Jingyuan Yang, Youxin Chen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06527274 (Effect of Defocus in Soft Contact Lenses on Internal Retinal Vascularization), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06527274 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Defocus in Soft Contact Lenses on Internal Retinal Vascularization

TypeinterventionalSponsorUniversité de MontréalRan2024 to 2025Enrolled25ConditionsNearsightednessArmsExperimental: Myopic defocus soft lens design (MDSL), Active Comparator: Single vision soft lens design (SVSL
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. New insights in pathogenic mechanism of hydroxychloroquine-induced ocular toxicity through choroidal imaging analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  2. The effect of heart rate variability on the choroidal vascularity of the optical coherence tomography and angiography in central serous chorioretinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erqian WangKey Laboratory of Ocular Fundus Disease, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Xinyu ZhaoKey Laboratory of Ocular Fundus Disease, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Jingyuan YangKey Laboratory of Ocular Fundus Disease, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Youxin ChenKey Laboratory of Ocular Fundus Disease, Chinese Academy of Medical Sciences, Beijing, 100730, China. chenyouxinpumch@hotmail.com.ORCID http://orcid.org/0000-0002-7231-5058
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2018PT32029
6 · The paper itself

Abstract

backgroundTo investigate swept-source optical coherence tomography angiography (SS-OCTA) for deep choroid visualization and choroidal vascular density (CVD) measurement.

methodsHealthy subjects and central serous chorioretinopathy (CSC) patients were recruited for macular SS-OCTA scans. We evaluated OCTA images at various depths to determine an optimal depth for visualizing choroidal vasculatures. We measured CVD with binarized OCTA images at the optimal depth. In healthy subjects, CVD was studied for its correlation with age, axial length (AL), and subfoveal choroidal thickness (SCT). In CSC eyes, CVD was compared with matched controls.

resultsNinety-one healthy eyes and 22 CSC eyes were included. SS-OCTA could display deep choroidal vasculatures as dark signals, with 100 μm beneath BM as the optimal depth. In healthy subjects, the CVD at 100 μm beneath BM (56.5 ± 10.9%) was significantly correlated with SCT (P = 0.004) but not with age (P = 0.49) or AL (P = 0.72). In CSC eyes, the CVD at 100 μm beneath BM (62.3 ± 6.6%) was larger than that in 22 matched controls (54.1 ± 8.0%) (P = 0.001). The difference remained statistically significant after adjusting for SCT (P = 0.02).

conclusionsSS-OCTA can be used for visualizing deep choroidal vasculatures. CVD measured by OCTA at 100 μm beneath BM is a useful parameter for quantifying choroidal vascular status.

Indexed as

Central Serous ChorioretinopathyTomography, Optical CoherenceChoroidFluorescein AngiographyHumansMicrovascular DensityVisual AcuityCentral serous chorioretinopathyChoroidal vascular densityOptical coherence tomography angiographySubfoveal choroidal thicknessSwept-source

Identifiers

PMID32758186
PMCPMC7409427
OpenAlexW3047099876

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.