Observational studyBMC nephrology2020
Depression does not predict clinical outcome of Chinese peritoneal Dialysis patients after adjusting for the degree of frailty.
Observational study in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frailty in peritoneal dialysis patients: a scoping review.Frontiers in medicine · 2026Pooled it
- The impact of serum myokine profile on the outcome of peritoneal dialysis patients.BMC nephrology · 2026Article
- Intramuscular fat content and the risk of peritonitis in peritoneal dialysis patients.Clinical kidney journal · 2026Article
- Prognostic Significance of Baseline Lean Tissue Mass Percentage in Incident Peritoneal Dialysis Patients.Kidney medicine · 2026Article
- Frailty in Focus: A Scoping Review of Frailty Instruments from the Kidney Disease Aging Research Collaborative.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Early change in lean tissue mass after peritoneal dialysis: prevalence, risk factors, and clinical implications.BMC nephrology · 2025Article
- Independent and joint influence of depression and advanced lung cancer inflammation index on mortality among individuals with chronic kidney disease.Frontiers in nutrition · 2024Article
- Prevalence of Depression and Its Associated Factors Among Hemodialysis Patients in Hodeida City, Yemen.Journal of multidisciplinary healthcare · 2024Article
- Mediating Role of Psychological Resilience Between Depression and Quality of Life in Maintenance Hemodialysis Patients in Baoding City, China: A Cross-Sectional Study.International journal of general medicine · 2024Article
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients.Scientific reports · 2022Article
- Interaction between central obesity and frailty on the clinical outcome of peritoneal dialysis patients.PloS one · 2020Article
- The Impact of Change in Body Roundness Index on the Clinical Outcome of New Peritoneal Dialysis Patients.Kidney diseases (Basel, Switzerland)Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundDepression and frailty contribute to the adverse clinical outcome of peritoneal dialysis (PD) patients. However, the interaction between depression and frailty in PD patients remains uncertain. We determined the prevalence of depression and frailty in prevalent Chinese PD patients, dissected the internal relationship between depression and frailty, and determined their relative contribution to the adverse clinical outcome in PD patients.
methodsIn a prospective observational study, we recruited 267 prevalent PD patients. Depression was identified by Patient Health Questionnaire (PHQ-9). Frailty was identified by a validated Frailty Score. All cases were followed for one year. Outcome measures included number and duration of hospitalization, peritonitis rate, and all-cause mortality.
resultsOf the 267 patients, 197 patients (73.8%) were depressed, and 157 (58.8%) were frail. There was a substantial overlap between depression and frailty. Although depression and frailty were associated the number and duration of hospitalization by univariate analysis, the association became insignificant after adjusting for confounding factors by multivariate analysis. Both depression and frailty were associated with one-year mortality by univariate analysis. One-year patient survival was 95.9, 86.5, 82.4 and 71.0% for patients with nil, mild, moderate and severe frailty, respectively (p = 0.001). Frailty was an independent predictor of patient survival by multivariate analysis (adjusted hazard ratio 1.424, 95% confidence interval 1.011-2.005. p = 0.043), while the prognostic effect of depression disappears after adjusting for frailty score.
conclusionDepression and frailty were common among Chinese PD patients. Frailty, but not depression, was an independent predictor of one-year mortality.
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