Evidence map›Paper›PMID 32758176›Full record

ArticleBMC neurology2020

The TRACK-PD study: protocol of a longitudinal ultra-high field imaging study in Parkinson's disease.

A F Wolters, M Heijmans, S Michielse, A F G Leentjens, A A Postma, J F A Jansen, D Ivanov, A A Duits, Y Temel, M L Kuijf

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

A F WoltersDepartment of Neurology, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands. amee.wolters@mumc.nl.ORCID http://orcid.org/0000-0003-2593-4056
M HeijmansSchool for Mental Health and Neuroscience, EURON, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
S MichielseSchool for Mental Health and Neuroscience, EURON, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
A F G LeentjensSchool for Mental Health and Neuroscience, EURON, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
A A PostmaSchool for Mental Health and Neuroscience, EURON, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
J F A JansenSchool for Mental Health and Neuroscience, EURON, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
D IvanovDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
A A DuitsSchool for Mental Health and Neuroscience, EURON, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Y TemelSchool for Mental Health and Neuroscience, EURON, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
M L KuijfDepartment of Neurology, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.
Maastricht University Medical Centre · NLMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe diagnosis of Parkinson's Disease (PD) remains a challenge and is currently based on the assessment of clinical symptoms. PD is also a heterogeneous disease with great variability in symptoms, disease course, and response to therapy. There is a general need for a better understanding of this heterogeneity and the interlinked long-term changes in brain function and structure in PD. Over the past years there is increasing interest in the value of new paradigms in Magnetic Resonance Imaging (MRI) and the potential of ultra-high field strength imaging in the diagnostic work-up of PD. With this multimodal 7 T MRI study, our objectives are: 1) To identify distinctive MRI characteristics in PD patients and to create a diagnostic tool based on these differences. 2) To correlate MRI characteristics to clinical phenotype, genetics and progression of symptoms. 3) To detect future imaging biomarkers for disease progression that could be valuable for the evaluation of new therapies.

methodsThe TRACK-PD study is a longitudinal observational study in a cohort of 130 recently diagnosed (≤ 3 years after diagnosis) PD patients and 60 age-matched healthy controls (HC). A 7 T MRI of the brain will be performed at baseline and repeated after 2 and 4 years. Complete assessment of motor, cognitive, neuropsychiatric and autonomic symptoms will be performed at baseline and follow-up visits with wearable sensors, validated questionnaires and rating scales. At baseline a blood DNA sample will also be collected. DISCUSSION: This is the first longitudinal, observational, 7 T MRI study in PD patients. With this study, an important contribution can be made to the improvement of the current diagnostic process in PD. Moreover, this study will be able to provide valuable information related to the different clinical phenotypes of PD and their correlating MRI characteristics. The long-term aim of this study is to better understand PD and develop new biomarkers for disease progression which may help new therapy development. Eventually, this may lead to predictive models for individual PD patients and towards personalized medicine in the future.

trial registrationDutch Trial Register, NL7558 . Registered March 11, 2019.

Indexed as

BrainMagnetic Resonance ImagingParkinson DiseaseBiomarkersCohort StudiesDisease ProgressionHumansLongitudinal StudiesObservational Studies as TopicPhenotypePrecision MedicineProspective StudiesSurveys and QuestionnairesBiomarkersBiomarkersCohort studiesParkinson’s diseaseUltra-high field MRI

Identifiers

PMID32758176
PMCPMC7409458
OpenAlexW3047021790

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.