Evidence map›Paper›PMID 32758153›Full record

SynthesisBMC anesthesiology2020

The correlation of intraoperative hypotension and postoperative cognitive impairment: a meta-analysis of randomized controlled trials.

Xiaojin Feng, Jialing Hu, Fuzhou Hua, Jing Zhang, Lieliang Zhang, Guohai Xu

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04963036 (Impact of Nociception Level), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04963036 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Impact of Nociception Level (NOL)-Guided Remifentanil Infusion and Entropy-guided Propofol Infusion on Intraoperative Arterial Pressure and Vasopressor Necessity A Prospective, Randomized, Controlled Trial.

TypeinterventionalSponsorCentre Hospitalier Universitaire Saint PierreRan2021 to 2022Enrolled50ConditionsHead and Neck Surgery, Maxillofacial SurgeryArmsEntropy and NOL-Guided Goal Directed Anesthesia, Standard of Care Group (Entropy and blinded NOL)
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaojin FengDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Jialing HuDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Fuzhou HuaDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Jing ZhangDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Lieliang ZhangDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Guohai XuDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. xuguohai1@sina.com.ORCID 0000-0002-0063-7410
Nanchang University · CN

Funding

National Nature Science Foundation of China 8176050165
6 · The paper itself

Abstract

backgroundThere is no consensus on whether intraoperative hypotension is associated with postoperative cognitive impairment. Hence, we performed a meta-analysis to evaluate the correlation of intraoperative hypotension and the incidence of postoperative delirium (POD) or postoperative cognitive dysfunction (POCD).

methodsWe searched PubMed, Embase, and Cochrane Library databases to find randomized controlled trials (RCTs) in which reported the relationship between intraoperative hypotension and POD or POCD. The retrieval time is up to January 2020, without language restrictions. Quality assessment of the eligible studies was conducted by two researchers independently with the Cochrane evaluation system.

resultsWe analyzed five eligible RCTs. Based on the relative mean arterial pressure (MAP), participants were divided into low-target and high-target groups. For the incidence of POD, there were two studies with 99 participants in the low-target group and 94 participants in the high-target pressure group. For the incidence of POCD, there were four studies involved 360 participants in the low-target group and 341 participants in the high-target group, with a study assessed both POD and POCD. No significant difference between the low-target and the high-target group was observed in the incidence of POD (RR = 3.30, 95% CI 0.80 to 13.54, P = 0.10), or POCD (RR = 1.26, 95% CI 0.76 to 2.08, P = 0.37). Furthermore, it also demonstrates that intraoperative hypotension prolonged the length of ICU stay, but did not increased the mortality, the length of hospital stay, and mechanical ventilation (MV) time.

conclusionsThere is no significant correlation between intraoperative hypotension and the incidence of POD or POCD.

Indexed as

HumansHypotensionIntensive Care UnitsIntraoperative ComplicationsLength of StayPostoperative Cognitive ComplicationsRandomized Controlled Trials as TopicIntraoperative hypotensionMeta-analysisPostoperative cognitive dysfunctionPostoperative delirium

Identifiers

PMID32758153
PMCPMC7409718
OpenAlexW3047352812

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.