Evidence map›Paper›PMID 32758145›Full record

Observational studyBMC cardiovascular disorders2020

Patterns of urinary albumin and IgM associate with markers of vascular ageing in young to middle-aged individuals in the Malmö offspring study.

Per Swärd, Rafid Tofik, Omran Bakoush, Ole Torffvit, Peter M Nilsson, Anders Christensson

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Per SwärdDepartment of Orthopedics, Clinical Sciences, Clinical and Molecular Osteoporosis Research Unit, Lund University, Skåne University Hospital, 205 02, Malmö, SE, Sweden. per.sward@skane.se.ORCID 0000-0003-1857-7089
Rafid TofikDepartment of Emergency medicine, Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Omran BakoushDepartment of Nephrology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.
Ole TorffvitDepartment of Nephrology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.
Peter M NilssonDepartment of Clinical Sciences and Internal Medicine, Lund University Skane University Hospital, Malmo, Sweden.
Anders ChristenssonDepartment of Nephrology, Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased urinary excretion of IgM and low-grade albuminuria are associated with increased risk of cardiovascular morbidity and mortality. The objective of this study was to investigate the association between urinary IgM, albuminuria, and vascular parameters reflecting arterial structure and function.

methodsSubjects of the present study were from the Malmö Offspring study (MOS) cohort, and included 1531 offspring (children and grand-children) to first-generation subjects that participated in the Malmö Diet Cancer-Cardiovascular Arm study cohort. At baseline, technical measurements of arterial stiffness (carotid-femoral pulse wave velocity; c-f PWV), carotid arterial morphology, 24-h ambulatory blood pressure recordings, ankle-brachial-index (ABI), and evaluation of endothelial function (reactive hyperemia index, RHI) were performed. Urinary (U) IgM, U-albumin, and U-creatinine were measured. Multivariate adjusted logistic regression was used to test whether U-IgM excretion and increasing urinary albumin excretion were related to vascular parameters.

resultsDetectable U-IgM was independently associated with higher systolic blood pressure, odds ratio (OR) 1.021, 95% confidence interval (CI, 1.003-1.039), p = 0.025 and lower ABI; ABI dx: OR 0.026, 95% CI (0.002-0.381), p = 0.008, ABI sin: OR 0.040, 95% CI (0.003-0.496), p = 0.012. Low-grade albuminuria was independently associated with systolic and diastolic blood pressure, aortic blood pressure, the c-f PWV and the number of carotid intima plaques (p < 0.05).

conclusionsIn young to middle-aged, mostly healthy individuals, increased U-IgM excretion and low-grade albuminuria are associated with adverse vascular parameters. Increased U-IgM excretion may reflect subclinical peripheral atherosclerosis, whereas increased U-albumin excretion is associated with a wide range of cardiovascular abnormalities. This may reflect different pathophysiological mechanisms.

Indexed as

Blood PressureGlomerular Filtration RateVascular StiffnessAdultAgedAge FactorsAgingAlbuminuriaCardiovascular DiseasesFemaleHeart Disease Risk FactorsHumansImmunoglobulin MKidneyMaleMiddle AgedImmunoglobulin MAlbumin creatinine ratioAnkle-brachial-indexArteriosclerosisAtherosclerosisGlomerular filtration barrierMicroalbuminuriaPulse wave velocityUrinary IgM

Identifiers

PMID32758145
PMCPMC7409481
OpenAlexW3047406437

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.