ArticleJournal of dental research2020
Genome-wide Analyses Identify a Novel Risk Locus for Nonsyndromic Cleft Palate.
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In one paragraph
Article in Journal of dental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Genome-wide meta-analyses identify five new risk loci for nonsyndromic orofacial clefts in the Chinese Han population.Molecular genetics & genomic medicine · 2023Pooled it
- Atlas of cell types and regulatory elements underlying human facial diversity.Nature genetics · 2026Article
- A study of sex-specific genetic effects underlying risk of orofacial clefts also highlights the potential impact of sequencing errors due to short read mis-mapping.medRxiv : the preprint server for health sciences · 2026Article
- Distinguishing syndromic and nonsyndromic cleft palate through analysis of protein-altering de novo variants in 818 trios.American journal of human genetics · 2025Article
- The cranial gland system of Nasonia spp.: a link between chemical ecology, evo-devo, and descriptive taxonomy (Hymenoptera: Chalcidoidea).Journal of insect science (Online) · 2025Article
- Functional variant at 19q13.3 confers nonsyndromic cleft palate susceptibility by regulatingiScience · 2025Article
- Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk.bioRxiv : the preprint server for biology · 2025Article
- Functional Validation of Noncoding Variants Associated With Nonsyndromic Orofacial Cleft.Human mutation · 2025Review
- High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.Nature communications · 2024Article
- Genome-wide study of gene-by-sex interactions identifies risks for cleft palate.Human genetics · 2024Article
- Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.Journal of human genetics · 2024Article
- Trio-based GWAS identifies novel associations and subtype-specific risk factors for cleft palate.HGG advances · 2023Article
- Trio-based GWAS identifies novel associations and subtype-specific risk factors for cleft palate.medRxiv : the preprint server for health sciences · 2023Article
- Identification of Novel Risk Variants of Non-Syndromic Cleft Palate by Targeted Gene Panel Sequencing.Journal of clinical medicine · 2023Article
- Chromatin conformation of human oral epithelium can identify orofacial cleft missing functional variants.International journal of oral science · 2022Article
- Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios.PLoS genetics · 2021Article
- Detecting Gene-Environment Interaction for Maternal Exposures Using Case-Parent Trios Ascertained Through a Case With Non-Syndromic Orofacial Cleft.Frontiers in cell and developmental biology · 2021Article
- Identification of Novel Variants in Cleft Palate-Associated Genes in Brazilian Patients With Non-syndromic Cleft Palate Only.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
35 authors at 7 institutions in 2 countries.
M HeThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
X ZuoDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
H LiuThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
W WangDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Y ZhangDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID 0000-0002-5988-2787
Y FuDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
Q ZhenDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Y YuThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
Y PanJiangsu Key Laboratory of Oral Diseases, School of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China.
C QinDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
B LiDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
R YangThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
J WuDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Z HuangThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
H GeDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
H WuThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
Q XuDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Y ZuoThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
W ChenDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Y QinThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
Z LiuStomatological Hospital of Nanyang, Nanyang, Henan, China.
S ChenDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
H ZhangDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
F ZhouDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
H YanStomatological Hospital of Xiangyang, Xiangyang, Hubei, China.
Y YuDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
L YongDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
G ChenDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
B LiangDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
R A CornellDepartment of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, IA, USA.
L ZongNanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
L WangJiangsu Key Laboratory of Oral Diseases, School of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China.
D ZouDepartment of Oral Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.ORCID 0000-0002-6985-5993
L SunDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Z BianThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.ORCID 0000-0002-8035-4276
Anhui Medical University · CNWuhan University · CNDeyang Stomatological Hospital · CNNanjing Medical University · CNNanjing Drum Tower Hospital · CNShanghai Jiao Tong University · CNUniversity of Iowa · US
Funding
Functional tests of non-coding DNA variants associated with risk for orofacial clefting.R01DE027362 · NIDCR · UNIVERSITY OF WASHINGTON · PI CORNELL, ROBERT AARON · 2018 to 2022
$2.2MNIDCR NIH HHS R01 DE027362
Abstract
The 3 major subphenotypes observed in patients with nonsyndromic orofacial clefts (NSOFCs) are nonsyndromic cleft lip only (NSCLO), nonsyndromic cleft lip with palate (NSCLP), and nonsyndromic cleft palate only (NSCPO). However, the genetic architecture underlying NSCPO is largely unknown. Here we performed a 2-stage genome-wide association study (GWAS) on NSCPO and replication analyses of selected variants in other NSOFCs from the Chinese Han population. We identified a novel locus (15q24.3) and a known locus (1q32.2) where variants in or near the gene reached genome-wide significance (2.80 × 10
Indexed as
Cleft LipCleft PalateAllelesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansPolymorphism, Single Nucleotidecommon variantsfunctional variantsgenetic risk locigenome-wide association studyorofacial cleftssusceptibility
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.