ArticleAnnals of Saudi medicine
Cystic fibrosis gene mutations and polymorphisms in Saudi men with infertility.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Beyond obstructive azoospermia: emerging insights into reproductive health in men with cystic fibrosis.Journal of assisted reproduction and genetics · 2026Review
- Novel insight into CFTR gene's single nucleotide variants classification via in-silico analysis of a conserved site.Journal of computer-aided molecular design · 2025Article
- Polymorphisms and expression levels of TNP2, SYCP3, and AZFa genes in patients with azoospermia.Clinical and experimental reproductive medicine · 2023Article
- Molecular targets for cystic fibrosis and therapeutic potential of monoclonal antibodies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome mutations of the cystic fibrosis transmembrane regulator (
objectiveAssess the frequency and analyze the spectrum of
designProspective, cross-sectional.
settingTertiary care specialist hospital in Jeddah. PATIENTS AND
methodsGenomic DNA was extracted from peripheral blood samples of Saudi men who presented with primary infertility to the outpatient andrology clinic with either azoospermia or oligoasthenoteratozoospermia. Polymerase chain reaction and direct sequencing were used to identify all variants of the
main outcome measuresProportion of the patients with a mutant SAMPLE SIZE: 50 infertile Saudi men.
resultsThis study identified 10 CFTR gene variants in 7 (14%) subjects (100 chromosomes). The detected variants and polymorphisms were: c.1408G>A, c.4389G>A, c.2562T>G, c.869+11C>T, c.2909-92G>A, c.3469-65C>A, c.1210-6delT, c.1210-6T>A, c.2988+1G>A, and c.1210-13GT>TG.
conclusionWe demonstrated that 14% of the study subjects had one or more LIMITATIONS: Small sample size and the lack of a control group. CONFLICTS OF INTEREST: None.
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