Trial reportAmerican journal of respiratory and critical care medicine2021
Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial.
Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 5 pooled it
10.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 5 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Pooled it
- Efficacy and Safety of Procalcitonin-Guided Antibiotic Therapy versus Standard of Care for Sepsis: A Systematic Review and Meta-Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Pooled it
- Antimicrobial stewardship interventions in hospitalized adults with community-acquired pneumonia: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Pooled it
- Procalcitonin-guided antibiotic therapy may shorten length of treatment and may improve survival-a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- Procalcitonin-guided antibiotic therapy for pediatrics with infective disease: A updated meta-analyses and trial sequential analysis.Frontiers in cellular and infection microbiology · 2022Pooled it
- Early diagnostic value of serum procalcitonin, C-reactive protein, white blood cell count and the neutrophil percentage in bacterial and fungal bloodstream infections.BMC immunology · 2026Article
- Article
- Blood cultures to define neonatal early-onset sepsis: why not enough for clinical care?Pediatric research · 2026Article
- Blood Transfusion Practices in Rural Hospitals: Indications, Challenges, and Practical Solutions.Cureus · 2026Review
- Prognostic value of dynamic procalcitonin (PCT-Δ) for adverse outcomes in patients with pyogenic liver abscess: a retrospective cohort study.BMC infectious diseases · 2026Article
- Clinical Impact of Droplet Digital PCR-Guided Antibiotic Stewardship on Prognosis in Patients with Suspected Bloodstream Infection: A Prospective Observational Study.Infectious diseases and therapy · 2026Article
- Efficacy of anakinra in reducing progression to organ dysfunction in patients with pneumonia (INSPIRE): a randomised, double-blind, placebo-controlled, phase IIa trial.The Lancet regional health. Europe · 2026Article
- Procalcitonin in the management of lower respiratory tract infection and sepsis.The Journal of antimicrobial chemotherapy · 2026Article
- Antimicrobial stewardship programs in sepsis treatment: principles, impact, and future directions.The Korean journal of internal medicine · 2026Review
- Synergistic Alleviation of Inflammatory Cytokine Storms in Sepsis Rats by Low-Intensity Pulsed Ultrasound and Imipenem.Mediators of inflammation · 2026Article
- Sepsis biomarkers: recent advances and future perspectives.Frontiers in immunology · 2026Review
- Early warning for acute pyelonephritis with sepsis: risk prediction model for patients without renal medullary necrosis lesions.Frontiers in medicine · 2026Article
- Point-of-care testing reduces antibiotic prescribing for adults with community-acquired pneumonia: a systematic review and meta-analysis.Frontiers in pharmacology · 2026Review
- Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis.Critical care (London, England) · 2025Article
- Optimal antibiotic use in the intensive care unit.Critical care (London, England) · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
27 authors at 6 institutions in 2 countries.
Evdoxia KyriazopoulouFourth Department of Internal Medicine and.
Lydia Liaskou-AntoniouFourth Department of Internal Medicine and.
George AdamisThird Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Antonia PanagakiFourth Department of Internal Medicine and.
Nikolaos MelachroinopoulosFourth Department of Internal Medicine and.
Elina DrakouThird Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Konstantinos MarousisThird Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Georgios ChrysosFirst Department of Internal Medicine, G. Gennimatas General Hospital of Athens, Athens, Greece.
Andronikos SpyrouThird Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Nikolaos AlexiouSecond Department of Internal Medicine, Tzaneio General Hospital of Piraeus, Athens, Greece.
Styliani SymbardiSecond Department of Internal Medicine, Tzaneio General Hospital of Piraeus, Athens, Greece.
Zoi AlexiouFirst Department of Internal Medicine and.
Styliani LagouSecond Department of Internal Medicine, Thriasio General Hospital of Eleusis, Athens, Greece; and.
Virginia KoloniaSecond Department of Internal Medicine, Sismanogleio General Hospital of Athens, Athens, Greece.
Theologia GkavogianniFourth Department of Internal Medicine and.
Miltiades KyprianouFourth Department of Internal Medicine and.
Ioannis AnagnostopoulosSecond Department of Internal Medicine, Thriasio General Hospital of Eleusis, Athens, Greece; and.
Garyfallia PoulakouSecond Department of Internal Medicine, Thriasio General Hospital of Eleusis, Athens, Greece; and.
Malvina LadaSecond Department of Internal Medicine, Sismanogleio General Hospital of Athens, Athens, Greece.
Anna MakinaFirst Department of Internal Medicine and.
Efrosyni RouliaFirst Department of Internal Medicine and.
Marina KoupetoriSecond Department of Internal Medicine, Tzaneio General Hospital of Piraeus, Athens, Greece.
Vasileios ApostolopoulosSecond Department of Internal Medicine, Tzaneio General Hospital of Piraeus, Athens, Greece.
Dimitra PetrouSecond Department of Internal Medicine, Tzaneio General Hospital of Piraeus, Athens, Greece.
Thomas NitsotolisFirst Department of Internal Medicine, G. Gennimatas General Hospital of Athens, Athens, Greece.
Anastasia AntoniadouFourth Department of Internal Medicine and.
Evangelos J Giamarellos-BourboulisFourth Department of Internal Medicine and.ORCID 0000-0003-4713-3911
Fourth State (United Kingdom) · GBTzaneion General Hospital · GRNational and Kapodistrian University of Athens · GRThriasio General Hospital of Elefsina · GRGeneral Hospital of Athens G. Genimatas · GRSismanoglio General Hospital · GR
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedAged, 80 and overAnti-Bacterial AgentsAntimicrobial StewardshipBiomarkersClostridioides difficileClostridium InfectionsDrug Administration ScheduleDrug MonitoringDrug Resistance, Multiple, BacterialFemaleFollow-Up StudiesGreeceHospital CostsHospitalizationAnti-Bacterial AgentsBiomarkersProcalcitoninmortalitymultidrug-resistantprocalcitoninsepsis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.