ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2020
APPEAL-2: A pan-European qualitative study to explore the burden of peanut-allergic children, teenagers and their caregivers.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Re-evaluating treatment success in trials of peanut oral-immunotherapy: impact of different definitions on efficacy outcomes.Current opinion in allergy and clinical immunology · 2025Pooled it
- Predictors of psychosocial burden in parents of children with food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Psychological Dimensions of Food Allergy: A Biopsychosocial and Neuropsychological Perspective.Nutrients · 2026Review
- Risk Perception in Food Allergy Sufferers: An Evolutionary Concept Analysis.Journal of food science · 2026Review
- Peanut Oral Immunotherapy in Children: An Italian Single-Center Retrospective Cohort Study.Nutrients · 2026Article
- Lived Experiences of School-Age Children with Food Allergies: A Qualitative Systematic Review and Meta-Synthesis.Children (Basel, Switzerland) · 2025Review
- Deriving Health Utilities from the Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF) Using Mapping and Discrete Choice Experiments.Patient related outcome measures · 2025Article
- Living with and Caring for People with Multiple Food Allergies: A Qualitative Study.Patient preference and adherence · 2024Article
- An investigation of a novel milk allergy-friendly food supplement program.Frontiers in allergy · 2024Article
- Impact of Presumed Tree Nut and Peanut Allergy on Quality of Life at Different Ages.Journal of clinical medicine · 2023Article
- Defining the window of opportunity and target populations to prevent peanut allergy.The Journal of allergy and clinical immunology · 2023Observational
- Post hoc analysis examining symptom severity reduction and symptom absence during food challenges in individuals who underwent oral immunotherapy for peanut allergy: results from three trials.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Peanut allergy burden survey: Factors associated with health-related quality of life in adolescents.Clinical and translational allergy · 2023Article
- Children and caregiver proxy quality of life from peanut oral immunotherapy trials.Clinical and translational allergy · 2022Article
- Qualitative interviews to understand health care providers' experiences of prescribing licensed peanut oral immunotherapy.BMC research notes · 2022Article
- Eight tips for the implementation of the first licenced peanut allergy oral immunotherapy into clinical practice.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Beliefs about food allergies in adolescents aged 11-19 years: A systematic review.Clinical and translational allergy · 2022Review
- Exploring Health-Related Quality of Life Burden in Peanut Allergy and the Potential Benefit of Oral Immunotherapy: Estimation of Health State Utility Values for Children and Adolescents and Their Caregivers.Patient preference and adherence · 2022Article
- Article
- The Peanut Allergy Burden Study: Impact on the quality of life of patients and caregivers.The World Allergy Organization journal · 2021Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllergy to Peanuts ImPacting Emotions And Life (APPEAL-1) was a recent European multi-country questionnaire survey that highlighted the negative impacts of peanut allergy (PA) on quality of life. A follow-on qualitative study, APPEAL-2, further assessed the burden of PA and associated coping strategies through semi-structured interviews.
objectiveTo gain qualitative insight on the strategies used to cope with and manage PA and the impact of these strategies on the quality of life of children, teenagers and caregivers.
methodsThis cross-sectional qualitative study was conducted in eight European countries: the United Kingdom, France, Germany, Ireland, Spain, Italy, Denmark and the Netherlands. Semi-structured interviews were conducted with children (aged 8-12 years) and teenagers (aged 13-17 years) with self-/proxy-reported moderate or severe PA and with parents/caregivers of children or teenagers (aged 4-17 years) with moderate or severe PA. Data were analysed using thematic analysis; data saturation was assessed. Two conceptual models were developed to illustrate the impacts of PA and coping strategies used to manage them for (a) individuals with PA and (b) parents/caregivers of children with PA.
results107 participants were interviewed: 24 children, 39 teenagers and 44 caregivers. The conceptual models illustrated themes related to coping and control, driven by the fear of PA reactions, and the associated emotional, social, relationship and work impacts. Factors moderating these impacts included social attitudes and support, child-caregiver relationship and coping strategies used. CONCLUSIONS AND CLINICAL RELEVANCE: The APPEAL-2 results substantiate the findings of APPEAL-1; the results also suggest that the severity of experience with PA may not correlate with perception of its overall burden and show variable impacts by country.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.