Trial reportBJOG : an international journal of obstetrics and gynaecology2021
Prognostic models versus single risk factor approach in first-trimester selective screening for gestational diabetes mellitus: a prospective population-based multicentre cohort study.
Trial report in BJOG : an international journal of obstetrics and gynaecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- First-Trimester Prediction Models Based on Maternal Characteristics for Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- Prognostic models versus single risk factor approach in first-trimester selective screening for gestational diabetes mellitus: a prospective population-based multicentre cohort study.BJOG : an international journal of obstetrics and gynaecology · 2021Trial
- First-Trimester Prediction of Gestational Diabetes Mellitus Based on Maternal Risk Factors.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Decision-making behavior of blood glucose management and its influencing factors in pregnant women with gestational diabetes mellitus.BMC pregnancy and childbirth · 2025Article
- Prevalence and Risk Factors of Gestational Diabetes Mellitus in Romania: Maternal and Fetal Outcomes.Medicina (Kaunas, Lithuania) · 2025Article
- A Complex mHealth Coaching Intervention to Prevent Overweight, Obesity, and Diabetes in High-Risk Women in Antenatal Care: Protocol for a Hybrid Type 2 Effectiveness-Implementation Study.JMIR research protocols · 2023Article
- Prediction of gestational diabetes mellitus in Asian women using machine learning algorithms.Scientific reports · 2023Article
- Cardiovascular Disease-Associated MicroRNAs as Novel Biomarkers of First-Trimester Screening for Gestational Diabetes Mellitus in the Absence of Other Pregnancy-Related Complications.International journal of molecular sciences · 2022Article
- Implementation of a first-trimester prognostic model to improve screening for gestational diabetes mellitus.BMC pregnancy and childbirth · 2021Article
- Article
- Older Underweight Pregnant Women Beat Young Overweight/Obese Ones on Incidence of Gestational Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Gestational Diabetes Mellitus-Innovative Approach to Prediction, Diagnosis, Management, and Prevention of Future NCD-Mother and Offspring.Frontiers in endocrinology · 2020Review
- Clinical and Biochemical Markers in Early Pregnancy for Prediction of Gestational Diabetes Mellitus.Indian journal of endocrinology and metabolismArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate whether (1) first-trimester prognostic models for gestational diabetes mellitus (GDM) outperform the currently used single risk factor approach, and (2) a first-trimester random venous glucose measurement improves model performance.
designProspective population-based multicentre cohort.
settingThirty-one independent midwifery practices and six hospitals in the Netherlands. POPULATION: Women recruited before 14 weeks of gestation without pre-existing diabetes.
methodsThe single risk factor approach (presence of at least one risk factor: BMI ≥30 kg/m
main outcome measuresDiscrimination was assessed by c-statistics, calibration by calibration plots, added value of glucose by the likelihood ratio chi-square test, net benefit by decision curve analysis and reclassification by reclassification plots.
resultsOf the 3723 women included, a total of 181 (4.9%) developed GDM. The c-statistics of the prognostic models were higher, ranging from 0.74 to 0.78 without glucose and from 0.78 to 0.80 with glucose, compared with the single risk factor approach (0.72). Models showed adequate calibration, and yielded a higher net benefit than the single risk factor approach for most threshold probabilities. Teede 2011 performed best in the reclassification analysis.
conclusionsFirst-trimester prognostic models seem to outperform the currently used single risk factor approach in screening for GDM, particularly when glucose was added as a predictor. TWEETABLE ABSTRACT: Prognostic models seem to outperform the currently used single risk factor approach in screening for gestational diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.