ArticleHuman brain mapping2020
Spatially coherent and topographically organized pathways of the human globus pallidus.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Deep brain stimulation in Lesch-Nyhan syndrome: a systematic review.Neurosurgical review · 2023Pooled it
- A multi-modal parcellation of human globus pallidus and its implications for symptom prediction and stratification in Parkinson's disease.BMC medicine · 2026Article
- Article
- Local Field Potentials in Movement Disorders: A Narrative Review.Stereotactic and functional neurosurgery · 2026Review
- Mechanisms and interventions promoting healthy frontostriatal dynamics in obsessive-compulsive disorder.Nature communications · 2025Article
- Intracranial electrophysiological biomarkers of compulsivity in obsessive-compulsive disorder.Nature. Mental health · 2025Article
- Track-Weighted Dynamic Functional Connectivity Profiles and Topographic Organization of the Human Pulvinar.Human brain mapping · 2024Article
- Exploring morphological similarity and randomness in Alzheimer's disease using adjacent grey matter voxel-based structural analysis.Alzheimer's research & therapy · 2024Article
- Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease.Translational neurodegeneration · 2023Review
- In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments.Frontiers in neuroscience · 2023Article
- Connectivity of corticostriatal circuits in nonmanifesting LRRK2 G2385R and R1628P carriers.CNS neuroscience & therapeutics · 2022Article
- In vivo probabilistic atlas of white matter tracts of the human subthalamic area combining track density imaging and optimized diffusion tractography.Brain structure & function · 2022Article
- Sex-related differences in adult attention-deficit hyperactivity disorder patients - An analysis of external globus pallidus functional connectivity in resting-state functional MRI.Frontiers in psychiatry · 2022Article
- Thalamic structural connectivity profiles in blepharospam/Meige's syndrome.NeuroImage. Clinical · 2022Article
- Striatal topographical organization: Bridging the gap between molecules, connectivity and behavior.European journal of histochemistry : EJH · 2021Review
- Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Striatal Direct Pathway Targets Npas1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Changes in Cerebral Gray and White Matter in Patients with Pantothenate Kinase-Associated Neurodegeneration: A Long-Term Magnetic Resonance Imaging Follow-Up Study.Journal of movement disorders · 2021Article
- Functional connectivity of the motor system in dystonia due to PKAN.eNeurologicalSci · 2021Article
- Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients.Medicina (Kaunas, Lithuania) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Internal and external segments of globus pallidus (GP) exert different functions in basal ganglia circuitry, despite their main connectional systems share the same topographical organization, delineating limbic, associative, and sensorimotor territories. The identification of internal GP sensorimotor territory has therapeutic implications in functional neurosurgery settings. This study is aimed at assessing the spatial coherence of striatopallidal, subthalamopallidal, and pallidothalamic pathways by using tractography-derived connectivity-based parcellation (CBP) on high quality diffusion MRI data of 100 unrelated healthy subjects from the Human Connectome Project. A two-stage hypothesis-driven CBP approach has been carried out on the internal and external GP. Dice coefficient between functionally homologous pairs of pallidal maps has been computed. In addition, reproducibility of parcellation according to different pathways of interest has been investigated, as well as spatial relations between connectivity maps and existing optimal stimulation points for dystonic patients. The spatial organization of connectivity clusters revealed anterior limbic, intermediate associative and posterior sensorimotor maps within both internal and external GP. Dice coefficients showed high degree of coherence between functionally similar maps derived from the different bundles of interest. Sensorimotor maps derived from the subthalamopallidal pathway resulted to be the nearest to known optimal pallidal stimulation sites for dystonic patients. Our findings suggest that functionally homologous afferent and efferent connections may share similar spatial territory within the GP and that subcortical pallidal connectional systems may have distinct implications in the treatment of movement disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.