ArticlePlant biotechnology journal2021
The apple bHLH transcription factor MdbHLH3 functions in determining the fruit carbohydrates and malate.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 123 citations in OpenAlex.
- Integrating genome-wide association study and transcriptomic profiling identifies candidate genes underlying soluble solids content in melon (Horticulture research · 2026Article
- Molecular mechanism of abscisic acid regulating bud-break through the NnTIFY10A/B-NnABI5 module in lotus.Horticulture research · 2026Article
- Chemometrics Combined with Multi-Source Spectroscopy for Fruit Germplasm Quality Evaluation: A Case Study on Quince (Foods (Basel, Switzerland) · 2026Article
- The MdERF17-MdbHLH149 Module Mediates Ethylene-Induced Starch Degradation Through the Transcriptional Repression of α-Amylase MdAMY1 in Apple.Plant biotechnology journal · 2026Article
- Article
- Molecular orchestration of malate and citrate metabolism: regulatory networks governing organic acid dynamics and fruit quality attributes.Horticulture research · 2026Article
- Dissecting fruit weight and quality traits in Australian passion fruit through genetic linkage mapping and QTL analysis.Frontiers in plant science · 2026Article
- Identification of candidate genes for malic acid content in tomato fruits and development of associated SNP markers.Frontiers in plant science · 2026Article
- Malate accumulation and transcriptome patterns during fruit development in sweet Cherry (Prunus avium L.).BMC plant biology · 2025Article
- Identification of Key Regulators Mediating Gamma-Aminobutyric Acid (GABA) and Organic Acid Accumulation in Strawberry.Plants (Basel, Switzerland) · 2025Article
- Malate metabolism in horticultural crops: mechanistic insights and agricultural practices for quality improvement.Molecular horticulture · 2025Review
- Article
- Transcriptomic Profiling Uncovers Molecular Basis for Sugar and Acid Metabolism in Two Pomegranate (Foods (Basel, Switzerland) · 2025Article
- Enrichment of two important metabolites D-galacturonic acid and D-glucuronic acid inhibits MdHb1-mediated fruit softening in apple.Nature plants · 2025Article
- Genome-Wide Identification and Expression Profiling of the Invertase Genes Involved in Sugar Metabolism and Accumulation inInternational journal of molecular sciences · 2025Article
- CitGATA7 interact with histone acetyltransferase CitHAG28 to promote citric acid degradation by regulating the glutamine synthetase pathway in citrus.Molecular horticulture · 2025Article
- Comparative Transcriptome Analysis Reveals Potential Molecular Regulation of Organic Acid Metabolism During Fruit Development in Late-Maturing Hybrid Citrus Varieties.International journal of molecular sciences · 2025Article
- The MADS-Box Transcription Factor EjAGL18 Negatively Regulates Malic Acid Content in Loquat by RepressingInternational journal of molecular sciences · 2025Article
- Population sequencing of cherry accessions unravels the evolution of Cerasus species and the selection of genetic characteristics in edible cherries.Molecular horticulture · 2025Article
- Whole-genome identification and functional analysis of grape bHLH transcription factors: new insights into the regulation of monoterpene biosynthesis.Frontiers in plant science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in carbohydrates and organic acids largely determine the palatability of edible tissues of horticulture crops. Elucidating the potential molecular mechanisms involved in the change in carbohydrates and organic acids, and their temporal and spatial crosstalk are key steps in understanding fruit developmental processes. Here, we used apple (Malus domestica Borkh.) as research materials and found that MdbHLH3, a basic helix-loop-helix transcription factor (bHLH TF), modulates the accumulation of malate and carbohydrates. Biochemical analyses demonstrated that MdbHLH3 directly binds to the promoter of MdcyMDH that encodes an apple cytosolic NAD-dependent malate dehydrogenase, activating its transcriptional expression, thereby promoting malate accumulation in apple fruits. Additionally, MdbHLH3 overexpression increased the photosynthetic capacity and carbohydrate levels in apple leaves and also enhanced the carbohydrate accumulation in fruits by adjusting carbohydrate allocation from sources to sinks. Overall, our findings provide new insights into the mechanism of how the bHLH TF MdbHLH3 modulates the fruit quality. It directly regulates the expression of cytosolic malate dehydrogenase MdcyMDH to coordinate carbohydrate allocation and malate accumulation in apple.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.