ArticleDiabetologia2020
The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study.
Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The bidirectional longitudinal association between depressive symptoms and HbADiabetic medicine : a journal of the British Diabetic Association · 2022Pooled it
- Treatment for comorbid depressive disorder or subthreshold depression in diabetes mellitus: Systematic review and meta-analysis.Brain and behavior · 2021Pooled it
- Glycemic excursion minimization in the management of type 2 diabetes: a novel intervention tested in a randomized clinical trial.BMJ open diabetes research & care · 2020Trial
- HbA1c and Cognitive Functioning Across Bipolar Disorder, Recurrent Major Depressive Disorder, and Schizophrenia: Findings from a Non-Diabetic Sample.Brain sciences · 2026Article
- Association between glycemic control, mental problems and nutrition in individuals with type 1 and type 2 diabetes mellitus in primary care settings.BMC public health · 2026Article
- An exploratory study of glycemic biomarkers and rTMS treatment outcomes in treatment-resistant depression.BMC psychiatry · 2026Article
- Association of serum HMGB1 and TLR4 levels with early-onset post-stroke depression in type 2 diabetes: a prospective cohort study.BMC neurology · 2026Article
- Metabolic Modulators in Depression: Emerging Molecular Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
- Insulin resistance and the risk of incident depression: the role of age, glycemic status, and adiposity in a prospective cohort study.The Lancet regional health. Western Pacific · 2025Article
- Associations between prenatal diabetes mellitus, social determinants of health, and postpartum psychopathology: A retrospective review within women with diabetes mellitus.Research square · 2025Article
- Neuropsychiatric Abnormalities in Metabolic Disturbances: Interplay of Adipokines and Neurotransmission.Molecular neurobiology · 2025Review
- Altered food liking in depression is driven by macronutrient composition.Psychological medicine · 2025Article
- The interface of depression and diabetes: treatment considerations.Translational psychiatry · 2025Review
- Meta-Analytic Insights Into Mindfulness Approaches for Depression and Diabetes Comorbidity Care.Diabetes spectrum : a publication of the American Diabetes Association · 2025Article
- Nonlinear association between depressive symptoms and homeostasis model assessment of insulin resistance: a cross-sectional analysis in the American population.Frontiers in psychiatry · 2025Article
- Correlation between estimated glucose disposal rate and diabetic depression: a population-based study.Frontiers in psychiatry · 2025Article
- Association between dietary patterns and depression symptoms among adults with or without diabetes in Qatar: a population-based study.BMC public health · 2024Article
- Temporal Relationship between HbA1c and Depressive Symptom Trajectories in a Longitudinal Cohort Study: The Mediating Role of Healthy Lifestyles.Brain sciences · 2024Article
- Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression.CNS neuroscience & therapeutics · 2024Review
- Prevalence and determinants of perinatal mental disorders in women with gestational diabetes in New Zealand: Findings from a national longitudinal study.Acta obstetricia et gynecologica Scandinavica · 2024Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisDepression is twice as common in individuals with type 2 diabetes as in the general population. However, it remains unclear whether hyperglycaemia and insulin resistance are directly involved in the aetiology of depression. Therefore, we investigated the association of markers of hyperglycaemia and insulin resistance, measured as continuous variables, with incident depressive symptoms over 4 years of follow-up.
methodsWe used data from the longitudinal population-based Maastricht Study (n = 2848; mean age 59.9 ± 8.1 years, 48.8% women, 265 incident depression cases, 10,932 person-years of follow-up). We assessed hyperglycaemia by fasting and 2 h post-load OGTT glucose levels, HbA
resultsFasting plasma glucose, 2 h post-load glucose and HbA CONCLUSIONS/
interpretationThe observed temporal association between hyperglycaemia and incident depressive symptoms in this study supports the presence of a mechanistic link between hyperglycaemia and the development of depressive symptoms. Graphical abstract.
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