Evidence map›Paper›PMID 32757135›Full record

ArticleBreast cancer research and treatment2020

A population-based study of invitation to and participation in clinical trials among women with early-stage breast cancer.

Monica A Patel, Jennifer L Shah, Paul H Abrahamse, Reshma Jagsi, Steven J Katz, Sarah T Hawley, Christine M Veenstra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Monica A PatelDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA.
Jennifer L ShahDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Paul H AbrahamseDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Reshma JagsiDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Steven J KatzDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Sarah T HawleyDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Christine M VeenstraDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA. cveenstr@med.umich.edu.ORCID http://orcid.org/0000-0001-9947-7156
University of Michigan · US

Funding

CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
GEORGIA COMPREHENSIVE CANCER CONTROL PROGRAMU58DP003875 · DP · GEORGIA DIVISION OF PUBLIC HEALTH · PI O'CONNOR, JEAN CATHERINE · 2012 to 2014
$15.9M
The Challenge of Individualizing Treatments for Patients with Breast CancerP01CA163233 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAWLEY, SARAH T · 2012 to 2016
$13.4M
ONCOLOGY RESEARCH TRAINING GRANTT32CA009357 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Qing Li · 1987 to 2026
$8.6M
Partner Engagement & Receipt of Surveillance in Colorectal Cancer SurvivorsK07CA196752 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VEENSTRA, CHRISTINE · 2016 to 2020
$848k
NCCDPHP CDC HHS U58 DP003862NCCDPHP CDC HHS U58 DP003875NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS HHSN261201300015CNCI NIH HHS K07 CA196752NCI NIH HHS P01 CA163233NCI NIH HHS T32 CA009357
6 · The paper itself

Abstract

purposeAlthough many studies clearly demonstrate disparities in cancer clinical trial enrollment, there is a lack of consensus on potential causes. Furthermore, virtually nothing is known about associations between patients' decision-making style and their participation in clinical trials.

methodsWomen with newly diagnosed, stage 0-II breast cancer reported to the Georgia and Los Angeles County Surveillance, Epidemiology, and End Results (SEER) registries in 2013-2014 were surveyed approximately seven months after diagnosis. We investigated two primary outcome variables: (1) invitation to participate in a clinical trial, (2) participation in a clinical trial. We evaluated bivariate associations using Chi-squared tests and used multivariable logistic regression models to investigate associations between patient variables, including decision-making style, and the primary outcomes.

results2578 patients responded (71% response rate); 30% were > age 65, 18% were black, 18% were Latina, 29% had ≤ high school education. 10% of patients reported invitation to participate in a clinical trial; 5% reported participation in a clinical trial. After adjustment younger age, receipt of chemotherapy or radiation, disease stage, and a more rational (versus more intuitive) decision-making style were associated with a higher odds of invitation to participate. Being married was associated with a higher odds of participation; having an annual family income ≥ $40,000 was associated with a lower odds of participation.

conclusions10% of patients reported invitation to participate in a clinical trial, and half of these reported participation. Invitation to participate varied by age and decision-making style, and participation varied by marital status and income.

Indexed as

Breast NeoplasmsAdultAgedAged, 80 and overBlack or African AmericanFemaleGeorgiaHispanic or LatinoHumansMiddle AgedPatient ParticipationSEER ProgramBreast cancerClinical trialDisparitiesEnrollmentParticipation

Identifiers

PMID32757135
PMCPMC7606336
OpenAlexW3047509597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.