ArticleEJNMMI physics2020
A realistic phantom of the human head for PET-MRI.
Article in EJNMMI physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Update on the Use of PET/MRI Contrast Agents and Tracers in Brain Oncology: A Systematic Review.International journal of nanomedicine · 2022Pooled it
- Standardized Images and Evaluation Metrics for Tomography.Tomography (Ann Arbor, Mich.) · 2026Article
- Gelatin-Based Head Phantoms: A Practical Guide for Artificial Brain Signal Research.International journal of biomaterials · 2026Article
- Assessment of lesion insertion tool in pelvis PET/MR data with applications to attenuation correction method development.Journal of applied clinical medical physics · 2024Article
- A review of harmonization strategies for quantitative PET.Annals of nuclear medicine · 2023Review
- 3D Extrusion Printing of Biphasic Anthropomorphic Brain Phantoms Mimicking MR Relaxation Times Based on Alginate-Agarose-Carrageenan Blends.ACS applied materials & interfaces · 2022Article
- A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Evaluating different methods of MR-based motion correction in simultaneous PET/MR using a head phantom moved by a robotic system.EJNMMI physics · 2022Article
- Multimodal phantoms for clinical PET/MRI.EJNMMI physics · 2021Review
- Standard MRI-based attenuation correction for PET/MRI phantoms: a novel concept using MRI-visible polymer.EJNMMI physics · 2021Article
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7 authors.
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Abstract
backgroundThe combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET-MRI) is a unique hybrid imaging modality mainly used in oncology and neurology. The MRI-based attenuation correction (MRAC) is crucial for correct quantification of PET data. A suitable phantom to validate quantitative results in PET-MRI is currently missing. In particular, the correction of attenuation due to bone is usually not verified by commonly available phantoms. The aim of this work was, thus, the development of such a phantom and to explore whether such a phantom might be used to validate MRACs.
methodVarious materials were investigated for their attenuation and MR properties. For the substitution of bone, water-saturated gypsum plaster was used. The attenuation of 511 keV annihilation photons was regulated by addition of iodine. Adipose tissue was imitated by silicone and brain tissue by agarose gel, respectively. The practicability with respect to the comparison of MRACs was checked as follows: A small flask inserted into the phantom and a large spherical phantom (serving as a reference with negligible error in MRAC) were filled with the very same activity concentration. The activity concentration was measured and compared using clinical protocols on PET-MRI and different built-in and offline MRACs. The same measurements were carried out using PET-CT for comparison.
resultsThe phantom imitates the human head in sufficient detail. All tissue types including bone were detected as such so that the phantom-based comparison of the quantification accuracy of PET-MRI was possible. Quantitatively, the activity concentration in the brain, which was determined using different MRACs, showed a deviation of about 5% on average and a maximum deviation of 11% compared to the spherical phantom. For PET-CT, the deviation was 5%.
conclusionsThe comparatively small error in quantification indicates that it is possible to construct a brain PET-MRI phantom that leads to MR-based attenuation-corrected images with reasonable accuracy.
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