Evidence map›Paper›PMID 32756974›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers.

Stephane Isnard, Rayoun Ramendra, John Lin, Sanket Kant, Brandon Fombuena, Jing Ouyang, Xiaorong Peng, Mohamed El Far, Cécile Tremblay, Nicole F Bernard and 1 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Cytomegalovirus Immunoglobulin G (IgG) Titer and Coronary Artery Disease in People With Human Immunodeficiency Virus (HIV).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023 · on this map
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Naïve CD4BMC immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephane IsnardChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Rayoun RamendraChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
John LinChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Sanket KantInfectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
Brandon FombuenaChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Jing OuyangChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Xiaorong PengChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Mohamed El FarDépartement de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Quebec, Canada.
Cécile TremblayDépartement de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Quebec, Canada.
Nicole F BernardInfectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
Jean-Pierre RoutyChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.

Funding

CIHR CTN 247CIHR HOP 103230CIHR PTJ 166049
6 · The paper itself

Abstract

Elite controllers (ECs) are people living with human immunodeficiency virus (HIV) who spontaneously control viral replication without antiretroviral therapy. We observed that elevated anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels correlated with annual CD4 T-cell count decay in ECs independently of age, sex, and human leukocyte antigen (HLA) type. Elevated anti-CMV titers may favor disease progression in ECs.

Indexed as

HIV-1HIV InfectionsCD4 Lymphocyte CountCD4-Positive T-LymphocytesCell CountCytomegalovirusHumansImmunoglobulin GViral LoadImmunoglobulin GCD4 decaycytomegaloviruselite controllersHIV

Identifiers

PMID32756974
PMCPMC8246824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.