ArticleThe Journal of clinical endocrinology and metabolism2020
Increased Body Mass Index Is Associated With A Nondilutional Reduction in Antimüllerian Hormone.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Does obesity affect serum anti-müllerian hormone or inhibin B levels in polycystic ovary syndrome? Results of a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2026Pooled it
- Effect of opportunistic salpingectomy at hysterectomy on anti-Müllerian hormone: A substudy of a randomized trial.Acta obstetricia et gynecologica Scandinavica · 2026Trial
- Incident endometriosis diagnosis and AMH: how surgical staging and typology relate to serum AMH levels.American journal of obstetrics and gynecology · 2026Article
- Cortisol-to-cortisone ratio postpartum is associated with anti-Müllerian hormone a decade later: evidence from a prospective study.Endocrine connections · 2026Article
- Age- and BMI-stratified assessment of serum anti-Müllerian hormone as a biomarker for polycystic ovary syndrome diagnosis in Chinese women.BMC endocrine disorders · 2026Article
- Association between body mass index and anti-Müllerian hormone in women with ovarian endometrioma and dermoid cyst.Frontiers in endocrinology · 2026Article
- Clinical characteristics and associated risk factors for diminished ovarian reserve among Chinese women: a matched case-control study.Frontiers in endocrinology · 2026Article
- Effect of body mass index on ovarian reserve and ART outcomes in infertile women: a large retrospective study.Journal of ovarian research · 2024Article
- The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women.International journal of molecular sciences · 2024Article
- The Relationship Between Anti-Müllerian Hormone and Body Composition Components in Patients With Polycystic Ovary Syndrome of Reproductive Age.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- The impact of obesity on reproductive health and metabolism in reproductive-age females.Fertility and sterility · 2024Review
- Utility of Serum Anti-Müllerian Hormone Measurement as Part of Polycystic Ovary Syndrome Diagnosis.Seminars in reproductive medicine · 2024Review
- Antimullerian Hormone, a Marker of Ovarian Reserve, Is Protective Against Presence and Severity of NASH in Premenopausal Women.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Evaluation of the relations between reproduction-related pituitary and ovarian hormones and abdominal fat area-related variables determined with computed tomography in overweight or obese women who have undergone bariatric surgery: a cross-sectional study.Quantitative imaging in medicine and surgery · 2023Article
- AMH in Males: Effects of Body Size and Composition on Serum AMH Levels.Journal of clinical medicine · 2023Article
- Serum anti-müllerian hormone (AMH) concentration during pregnancy: a longitudinal study.Reproduction & fertility · 2023Article
- The reference value of anti-Müllerian hormone to diagnose polycystic ovary syndrome is inversely associated with BMI: a retrospective study.Reproductive biology and endocrinology : RB&E · 2023Article
- The relationship between anti-Müllerian hormone, body mass index and weight loss: A review of the literature.Clinical obesity · 2022Review
- Long-term antimüllerian hormone patterns differ by cancer treatment exposures in young breast cancer survivors.Fertility and sterility · 2022Article
- Anti-Müllerian hormone was independently associated with central obesity but not with general obesity in women with PCOS.Endocrine connections · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
contextControversy exists regarding if and how body mass index (BMI) impacts antimüllerian hormone (AMH) in women with and without polycystic ovary syndrome (PCOS). Understanding the BMI-AMH relationship has critical implications for clinical interpretation of laboratory values and could illuminate underlying ovarian physiology.
objectiveTo test the hypotheses that (1) BMI is associated with reduced AMH in PCOS and ovulatory controls (OVAs) and (2) the reduction in AMH is not accounted for by dilutional effects. DESIGN/
settingMulticenter cohort.
participantsWomen aged 25 to 40 years from 2 clinical populations: 640 with PCOS, 921 women as OVAs.
main outcome measuresOvarian reserve indices: AMH, antral follicle count (AFC), and AMH to AFC ratio (AMH/AFC) as a marker of per-follicle AMH production.
resultsIn both cohorts, increasing BMI and waist circumference were associated with reductions in AMH and AMH/AFC, after adjusting for age, race, smoking, and site in multivariate regression models. Increasing BMI was associated with reduced AFC in PCOS but not OVAs. Body surface area (BSA), which unlike BMI is strongly proportional to plasma volume, was added to investigate a potential dilutive effect of body size on AMH concentrations. After controlling for BSA, BMI retained independent associations with AMH in both cohorts; BSA no longer associated with AMH.
conclusionsIn an adjusted analysis, BMI, but not BSA, was associated with reduced AMH; these data do not support a role for hemodilution in mediating the relationship between increased body size and reduced AMH. Decreased AMH production by the follicle unit may be responsible for reduced AMH with increasing BMI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.