Evidence map›Paper›PMID 32756866›Full record

ArticleBioscience reports2020

Association between plasma betaine levels and dysglycemia in patients with coronary artery disease.

Fei Guo, Xueting Qiu, Yuanting Zhu, Zhirong Tan, Zhenyu Li, Dongsheng Ouyang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fei GuoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Xueting QiuDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, China.
Yuanting ZhuDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, China.
Zhirong TanDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Zhenyu LiDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, China.
Dongsheng OuyangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary betaine intake was reported to associate with favorable profile of metabolic disorders. However, the role of circulating betaine in coronary artery disease (CAD) patients with dysglycemia is still unknown. The present study aimed to investigate the potential associations between plasma betaine levels and dysglycemia in CAD patients.

methodsTotal 307 subjects were enrolled in the present study with 165 CAD patients (57 with dysglycemia and 108 with normal glycemia) and 142 age- and sex-matched controls (CON). Fasting plasma betaine was detected using liquid chromatography tandem mass spectrometry.

resultsPlasma betaine was lower in normal glycemia CAD patients (28.29 (22.38-35.73) μM) compared with healthy controls (29.75 (25.32-39.15) μM), and was further decreased in CAD patients with dysglycemia (24.14 (20.84-30.76) μM, P<0.01). Betaine levels were inversely correlated with fasting glucose, glycated hemoglobin% (HbA1c), diastolic blood pressure (DBP), triglyceride (TG) and alanine aminotransferase (ALT) levels (all, P≤0.05). Subjects in the highest betaine tertile group had lowest frequency of CAD and dysglycemia (all, P<0.01). Increased betaine levels were independently associated with low risk of dysglycemia in CAD after adjustment for multiple traditional risk factors (OR = 0.04, 95% CI: 0-0.37, P=0.01). Furthermore, betaine had good performance at distinguishing CAD with dysglycemia from normal glycemia CAD (AUC = 0.62, P<0.01).

conclusionPlasma betaine levels are independently and inversely associated with dysglycemia in CAD after adjustment for multiple factors, and may be useful for risk stratification of dysglycemia in CAD.

Indexed as

AdultAgedBetaineBiomarkersBlood GlucoseCase-Control StudiesChromatography, High Pressure LiquidCoronary Artery DiseaseCross-Sectional StudiesDiabetes MellitusFemaleGlycated HemoglobinHumansMaleMiddle AgedPrediabetic StateBetaineBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanbetaineCADcross-sectionaldysglycemia

Identifiers

PMID32756866
PMCPMC7432995
OpenAlexW3047018647

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.