ArticlePloS one2020
The environmental risk assessment of cell-processing facilities for cell therapy in a Japanese academic institution.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 19 citations in OpenAlex.
- Environmental monitoring practices relevant to regenerative medicine manufacturing: Insights from a cross-sector survey of regulated facilities in Japan.Regenerative therapy · 2026Article
- Biosafety-cabinet wipe-cleaning assessment system: Integration of visual, thermal, and pressure sensing.Regenerative therapy · 2026Article
- Microbial contamination risks and clinical safety in platelet-rich plasma therapy and evaluation of rapid microbial detection methods.Regenerative therapy · 2026Article
- Optimized personnel flow with minimal contamination: development and validation of an air-barrier cleanroom for cell products processing.Regenerative therapy · 2025Article
- Microbiome-based profiles of airborne bacteria to support microbial risk assessment in cleanroom environments.Regenerative therapy · 2025Article
- Operator stress factors and cell contamination risks in cell processing facilities: An online survey-based analysis.Regenerative therapy · 2025Article
- Cleaning methods for biosafety cabinet to eliminate residual mycoplasmas, viruses, and endotoxins after changeover.Regenerative therapy · 2025Article
- Changeover method for biosafety cabinets using ozone gas.PloS one · 2025Article
- The environmental microbial retrieving assessment of cell-processing facilities for cell therapy in a hospital laboratory.Microbiology spectrum · 2024Article
- Decreasing electricity costs of clean room for cell products during non-operation.Regenerative therapy · 2024Article
- Evaluation of cleaning methods for change-over after the processing of cell products to avoid cross-contamination risk.Regenerative therapy · 2024Article
- Remote audit practice for inspection of structural and equipment standards for cell processing facilities under the act on the safety of regenerative medicine in Japan.Regenerative therapy · 2024Article
- Operator-derived particles and falling bacteria in biosafety cabinets.Regenerative therapy · 2024Article
- Volatile organic compounds and ionic substances contamination in cell processing facilities during rest period; a preliminary assessment of exposure to cell processing operators.Regenerative therapy · 2023Article
- Effect of disinfectants and manual wiping for processing the cell product changeover in a biosafety cabinet.Regenerative therapy · 2023Article
- Cross-contamination risk and decontamination during changeover after cell-product processing.Regenerative therapy · 2023Article
- Assessment of microbial contamination in laser materials processing laboratories used for prototyping of biomedical devices.Access microbiology · 2023Article
- Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey.Regenerative therapy · 2022Article
- Safety of using cultured cells with trisomy 7 in cell therapy for treating osteoarthritis.Regenerative therapy · 2022Review
- Ultrasound-Guided Harvesting of Synovium for Regenerative Medicine of Cartilage and Meniscus Using Synovial Mesenchymal Stem Cells.Arthroscopy techniques · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell therapy is a promising treatment. One of the key aspects of cell processing products is ensuring sterility of cell-processing facilities (CPFs). The objective of this study was to assess the environmental risk factors inside and outside CPFs. We monitored the temperature, humidity, particle number, colony number of microorganisms, bacteria, fungi, and harmful insects in and around our CPF monthly over one year. The temperature in the CPF was constant but the humidity fluctuated depending on the humidity outside. The particle number correlated with the number of entries to the room. Except for winter, colonies of microorganisms and harmful insects were detected depending on the cleanliness of the room. Seven bacterial and two fungal species were identified by PCR analyses. Psocoptera and Acari each accounted for 41% of the total trapped insects. These results provide useful data for taking the appropriate steps to keep entire CPFs clean.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.