Evidence map›Paper›PMID 32756443›Full record

ReviewVaccines2020

Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine.

Christopher E Lopez, Kevin L Legge

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  15. Mucosal Administration ofJournal of microbiology and biotechnology · 2024
    Article
  16. Article
  17. Naturally occurring PAVirologica Sinica · 2024
    Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher E LopezDepartment of Microbiology and Immunology University of Iowa, Iowa City, IA 52242, USA.
Kevin L LeggeDepartment of Microbiology and Immunology University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-9800-6854
University of Iowa · US

Funding

Universal room temperature stable influenza nanovaccineR01AI141196 · NIAID · IOWA STATE UNIVERSITY · PI NARASIMHAN, BALAJI · 2019 to 2023
$5.6M
Nanovaccine-Mediated Immune Protection Against Influenza VirusR01AI127565 · NIAID · UNIVERSITY OF IOWA · PI LEGGE, KEVIN L, WALDSCHMIDT, THOMAS J · 2017 to 2021
$2.8M
Training in Molecular Virology, Viral Pathogenesis and Viral VectorsT32AI007533 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 1998 to 2026
$2.5M
NIAID NIH HHS R01 AI127565NIAID NIH HHS R01 AI141196NIAID NIH HHS T32 AI007533NIH HHS R01AI127565NIH HHS R01AI141196
6 · The paper itself

Abstract

Influenza virus infections represent a serious public health threat and account for significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. Despite being an important countermeasure to combat influenza virus and being highly efficacious when matched to circulating influenza viruses, current preventative strategies of vaccination against influenza virus often provide incomplete protection due the continuous antigenic drift/shift of circulating strains of influenza virus. Prevention and control of influenza virus infection with vaccines is dependent on the host immune response induced by vaccination and the various vaccine platforms induce different components of the local and systemic immune response. This review focuses on the immune basis of current (inactivated influenza vaccines (IIV) and live attenuated influenza vaccines (LAIV)) as well as novel vaccine platforms against influenza virus. Particular emphasis will be placed on how each platform induces cross-protection against heterologous influenza viruses, as well as how this immunity compares to and contrasts from the "gold standard" of immunity generated by natural influenza virus infection.

Indexed as

adaptive immunityantibodyinfluenza virusT cellsvaccine

Identifiers

PMID32756443
PMCPMC7565301
OpenAlexW3046232964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.