ReviewAnimals : an open access journal from MDPI2020
Research on the Applications of Calcium Propionate in Dairy Cows: A Review.
Review in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Meta-analytic effect ofFrontiers in veterinary science · 2022Pooled it
- Article
- Sustainable Synthesis of Calcium Propionate from Cockle Shell Biowaste for Food Additive Production.International journal of molecular sciences · 2026Article
- The Future Toolbox for Managing Ketosis in Dairy Cow Herds: A European Key Opinion Leader Consensus.Veterinary sciences · 2026Article
- Current Understanding of Bovine Ketosis: From Molecular Basis to Farm-Level Management.Animals : an open access journal from MDPI · 2025Review
- Sucrose supplementation mitigates heat stress-induced alterations in rumen metabolism and immunity in dairy cows.Scientific reports · 2025Article
- Food Preservatives and the Rising Tide of Early-Onset Colorectal Cancer: Mechanisms, Controversies, and Emerging Innovations.Foods (Basel, Switzerland) · 2025Review
- Understanding the differences in rumen bacteria and their impact on dairy cows' production performance: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Impact of subclinically hypocalcemic stress on the plasma metabolomic profile of dairy goats.Animal bioscience · 2025Article
- Optimal Period of Calcium Propionate Supplementation in Arrival High-Risk Bull Calves: Growth Performance, Body Fat Reserves, and Serum Metabolites.Animals : an open access journal from MDPI · 2025Article
- Subclinical hypocalcemia in dairy cows: reproductive and economic impacts on Eastern European farms.Frontiers in veterinary science · 2025Article
- Recent nutritional strategies and feed additives to stimulate proper rumen development in young goats.Translational animal science · 2025Article
- Growth Performance, Rumen Fermentation, and Meat Quality of Finishing Lambs Supplemented with Calcium Propionate or Sodium Propionate.Veterinary sciences · 2024Article
- Propionate production by Bacteroidia gut bacteria and its dependence on substrate concentrations differs among species.Biotechnology for biofuels and bioproducts · 2024Article
- Differences of serum glucose and lipid metabolism and immune parameters and blood metabolomics regarding the transition cows in the antepartum and postpartum period.Frontiers in veterinary science · 2024Article
- Microbial feed additives in ruminant feeding.AIMS microbiology · 2024Review
- Article
- Effects of Chromium Propionate and Calcium Propionate on Lactation Performance and Rumen Microbiota in Postpartum Heat-Stressed Holstein Dairy Cows.Microorganisms · 2023Article
- Effects of maternal calcium propionate supplementation on offspring productivity and meat metabolomic profile in sheep.PloS one · 2023Article
- Alterations in the Milk Metabolome of Dairy Cows Supplemented with Different Levels of Calcium Propionate in Early Lactation.Metabolites · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Calcium propionate is a safe and reliable food and feed additive. It can be metabolized and absorbed by humans and animals as a precursor for glucose synthesis. In addition, calcium propionate provides essential calcium to mammals. In the perinatal period of dairy cows, many cows cannot adjust to the tremendous metabolic, endocrine, and physiological changes, resulting in ketosis and fatty liver due to a negative energy balance (NEB) or milk fever induced by hypocalcemia. On hot weather days, cow feed (TMR or silage) is susceptible to mildew, which produces mycotoxins. These two issues are closely related to dairy health and performance. Perinatal period metabolic disease significantly reduces cow production and increases the elimination rate because it causes major glucose and calcium deficiencies. Feeding a diet contaminated with mycotoxin leads to rumen metabolic disorders, a reduced reproductive rate (increased abortion rate), an increased number of milk somatic cells, and decreased milk production, as well as an increased occurrence of mastitis and hoof disease. Propionic acid is the primary gluconeogenic precursor in dairy cows and one of the safest mold inhibitors. Therefore, calcium propionate, which can be hydrolyzed into propionic acid and Ca
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.