ArticleMedicine2020
Real dynamic assessment of tear film optical quality for monitoring and early prevention of dry eye.
Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05923528 (Comparison of Non-pharmaceutical Treatments for Evaporative Dry Eye), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Non-pharmaceutical Treatments for Evaporative Dry Eye: A Randomized Controlled Study
Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- The role of corneal epithelial thickness parameters with different degrees of keratoconus in the diagnosis of keratoconus.Molecular vision · 2026Article
- Dry eye disease in systemic lupus erythematosus: a cross sectional study.International journal of ophthalmology · 2024Article
- Tear film instability is associated with weakened colocalization between occludin and MUC5AC in scopolamine-induced dry eye disease (DED) rats.International ophthalmology · 2023Article
- Assessing the correlation between swept-source optical coherence tomography lens density pattern analysis and best-corrected visual acuity in patients with cataracts.BMJ open ophthalmology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate real dynamic assessment of tear film optical quality for monitoring and prevention of dry eye.Right eyes of 62 normal and 39 dry eye subjects were included. Dynamic measurement of objective scatter index (OSI) was performed by using the Optical Quality Analysis System II (OQAS II), correlation coefficient between OSI and time (CCOT) was calculated. According to whether the CCOT was significantly ascending, normal and dry eye groups were further subdivided for comparison. By using Scheimpflug-Placido topographer, non-invasive tear break-up time (NITBUT) was recorded, and a 2-dimensional precorneal tear film map was reconstructed and divided into central, middle, and peripheral corneal zones, distribution of tear break-up spots in the 3 corneal zones were analyzed.The numbers of tear break-up spots were higher in all the 3 corneal zones of the dry eye subjects (P < .01), when compared with the normal subjects. The Dry Eye subjects with ascending CCOT had the shortest NITBUT (P < .001-.034) and the most tear break-up spots over the whole cornea (P < .001-.044). Between the dry eye subjects with non-ascending CCOT and those with ascending CCOT, difference of tear break-up spots was found significant only in the peripheral corneal zone (P < .01).Non-ascending and ascending CCOT of dry eye patients reflect different stability of tear film. Real dynamic assessment of tear film optical quality is potential for monitoring and early prevention of dry eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.