Evidence map›Paper›PMID 32755992›Full record

ReviewEuropean journal of endocrinology2020

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19.

John P Bilezikian, Daniel Bikle, Martin Hewison, Marise Lazaretti-Castro, Anna Maria Formenti, Aakriti Gupta, Mahesh V Madhavan, Nandini Nair, Varta Babalyan, Nicholas Hutchings and 5 more

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04810949 (Effect of Vitamin D Supplementation on the Development of Respiratory Infections), which is not on this map. Cited by 211 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 14 pooled it
43.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04810949 naterminatednot on this map

Effect of Vitamin D Supplementation on the Development of Respiratory Infections (COVID-19) in Health Personnel at Hospital Clínica NOVA With Serum Values> 20ng / ml

TypeinterventionalSponsorHospital Clinica NovaRan2020 to 2021Enrolled41ConditionsCovid19, Influenza A, Influenza B, H1N1 InfluenzaArmsVitamine D3 supplementation, Diet and sun exposure
3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 14 syntheses or guidelines pooled it, 348 citations in OpenAlex.

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  15. Effect of vitamin DClinics (Sao Paulo, Brazil) · 2024
    Trial
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  20. Review

151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 5 countries.

John P BilezikianEndocrinology Division, Department of Medicine, New York-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-1570-2617
Daniel BikleEndocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California, USA.
Martin HewisonInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Marise Lazaretti-CastroDivision of Endocrinology, Escola Paulista de Medicina - Universidade Federal de Sao Paulo (EPM-UNIFESP), Sao Paulo, Brazil.
Anna Maria FormentiInstitute of Endocrine and Metabolic Sciences, San Raffaele, Vita-Salute University and IRCCS Hospital, Milano, Italy.
Aakriti GuptaDivision of Cardiology, Department of Medicine, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.
Mahesh V MadhavanDivision of Cardiology, Department of Medicine, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.
Nandini NairEndocrinology Division, Department of Medicine, New York-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.
Varta BabalyanOsteoporosis Center of Armenia, Yerevan, Armenia.
Nicholas HutchingsSchool of Medicine, University of California, Irvine, California, USA.ORCID 0000-0001-9964-142X
Nicola NapoliUnit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy.
Domenico AcciliEndocrinology Division, Department of Medicine, New York-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.
Neil BinkleyUniversity of Wisconsin, Madison, Wisconsin, USA.
Donald W LandryDivision of Nephrology, Department of Medicine, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.
Andrea GiustinaInstitute of Endocrine and Metabolic Sciences, San Raffaele, Vita-Salute University and IRCCS Hospital, Milano, Italy.
NewYork–Presbyterian Hospital · USVita-Salute San Raffaele University · ITNational Statistical Service of the Republic of Armenia · AMSan Francisco VA Medical Center · USUniversidade Federal de São Paulo · BRUniversità Campus Bio-Medico · ITUniversity of Birmingham · GBUniversity of California, Irvine · USUniversity of Wisconsin–Madison · USYale New Haven Hospital · US

Funding

Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Anthony W Ferrante · 2003 to 2026
$36.7M
Training Medical Students in NIDDK ResearchT35DK093430 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QAIS AL-AWQATI, Utpal Pajvani · 2012 to 2026
$1.3M
NIDDK NIH HHS P30 DK063608
6 · The paper itself

Abstract

The SARS-CoV-2 virus responsible for the COVID-19 pandemic has generated an explosion of interest both in the mechanisms of infection leading to dissemination and expression of this disease, and in potential risk factors that may have a mechanistic basis for disease propagation or control. Vitamin D has emerged as a factor that may be involved in these two areas. The focus of this article is to apply our current understanding of vitamin D as a facilitator of immunocompetence both with regard to innate and adaptive immunity and to consider how this may relate to COVID-19 disease. There are also intriguing potential links to vitamin D as a factor in the cytokine storm that portends some of the most serious consequences of SARS-CoV-2 infection, such as the acute respiratory distress syndrome. Moreover, cardiac and coagulopathic features of COVID-19 disease deserve attention as they may also be related to vitamin D. Finally, we review the current clinical data associating vitamin D with SARS-CoV-2 infection, a putative clinical link that at this time must still be considered hypothetical.

Indexed as

Adaptive ImmunityAntimicrobial Cationic PeptidesAutophagyBetacoronavirusCathelicidinsCoronavirus InfectionsCOVID-19Cytokine Release SyndromeDefensinsHumansImmunity, InnateImmunocompetenceLungPandemicsPneumonia, ViralSARS-CoV-21,25-dihydroxyvitamin DAntimicrobial Cationic PeptidesCathelicidinsDefensinsVitamin D

Identifiers

PMID32755992
PMCPMC9494342
OpenAlexW3047469750

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.