Evidence map›Paper›PMID 32755646›Full record

ReviewBrain, behavior, and immunity2020

Longitudinal associations between circulating interleukin-6 and C-reactive protein in childhood, and eating disorders and disordered eating in adolescence.

Francesca Solmi, Cynthia M Bulik, Bianca L De Stavola, Christina Dalman, Golam M Khandaker, Glyn Lewis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review and meta-analysis of loss-of-control eating in relation to cardiometabolic health components and inflammatory markers.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Gut Microbiome Changes in Anorexia Nervosa: A Comprehensive Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca SolmiDivision of Psychiatry, UCL, London, UK. Electronic address: Francesca.solmi@ucl.ac.uk.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, USA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Bianca L De StavolaGreat Ormond Street Institute of Child Health, UCL, London UK.
Christina DalmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Golam M KhandakerUniversity of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Glyn LewisDivision of Psychiatry, UCL, London, UK.

Funding

Empirical eating disorder classification and validation using prospective studiesR01MH087786 · NIMH · BROWN UNIVERSITY · PI FIELD, ALISON E, MICALI, NADIA · 2010 to 2014
$2.5M
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_17213Medical Research Council MC_PC_19009NIMH NIH HHS R01 MH087786Wellcome TrustWellcome Trust 201486/Z/16/ZWellcome Trust 209196/Z/17/Z
6 · The paper itself

Abstract

objectiveFew studies have explored the association between inflammation and eating disorders and none used a longitudinal design. We investigated the association between serum-levels of interleukin 6 (IL-6) and C-reactive protein (CRP) measured in childhood and eating disorders and related behaviours and cognitions in adolescence in a large general population sample.

methodsWe used data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Our exposures were thirds of IL6 and CRP derived from serum measurements taken at age nine years, and outcomes were eating disorder diagnoses and self-reported disordered eating behaviours at ages 14, 16, and 18 years. We used univariable and multivariable multilevel logistic regression models adjusting for a number of potential confounders, including sex, fat mass, and pre-existing mental health difficulties.

resultsOur sample included 3480 children. Those in the top third of CRP had lower odds of binge eating (odds ratio(OR):0.62, 95% confidence interval (CI):0.39,1.00,p "equals" 0.05) and fasting (OR:0.63, 95% CI:0.38,1.07,p "equals" 0.09) after adjustment for confounders. We also observed weak associations of comparable magnitude for purging, anorexia nervosa, and bulimia nervosa. We did not find any associations between levels of IL6 and any of the outcomes under study.

conclusionsThere was little evidence of an association between CRP and IL-6 and adolescent eating disorder outcomes. The inverse association observed between CRP and binge eating was unexpected, so caution is needed when interpreting it. One possible explanation is that higher CRP levels could have a protective role for disordered eating by affecting appetitive traits.

Indexed as

Bulimia NervosaFeeding and Eating DisordersAdolescentCausalityChildC-Reactive ProteinHumansInterleukin-6Longitudinal StudiesC-Reactive ProteinInterleukin-6ALSPACCohort studyCRPEating disordersIL6Inflammation

Identifiers

PMID32755646
PMCPMC7902903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.