Evidence map›Paper›PMID 32755639›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2020

Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions.

Aleah Holmes, Carson Finger, Diego Morales-Scheihing, Juneyoung Lee, Louise D McCullough

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 76 citations in OpenAlex.

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  14. Gut microbial metabolism in Alzheimer's disease and related dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aleah HolmesDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.
Carson FingerDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.
Diego Morales-ScheihingDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.
Juneyoung LeeDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.
Louise D McCulloughDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas. Electronic address: Louise.D.McCullough@uth.tmc.edu.
The University of Texas Health Science Center at Houston · US

Funding

Dynamic Non-Neuronal Interactions between the Gut Microbiota and the Brain in Aging and in Cerebral Amyloid AngiopathyRF1AG058463 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BRYAN, ROBERT M, MCCULLOUGH, LOUISE D. · 2017 to 2017
$3.7M
Detrimental Effects of Age Related DysbiosisR01NS103592 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BRYAN, ROBERT M, MCCULLOUGH, LOUISE D. · 2018 to 2022
$3.2M
Reversing Age Related InflammationR01NS094543 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCCULLOUGH, LOUISE D. · 2016 to 2020
$2.8M
Psychosocial Stress and Behavioral Response to StrokeR01NS077769 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MCCULLOUGH, LOUISE D. · 2011 to 2014
$2.3M
NIA NIH HHS RF1 AG058463NINDS NIH HHS R01 NS077769NINDS NIH HHS R01 NS094543NINDS NIH HHS R01 NS103592
6 · The paper itself

Abstract

The gut microbiota is a complex ecosystem of bacteria, fungi, and viruses that acts as a critical regulator in microbial, metabolic, and immune responses in the host organism. Imbalances in the gut microbiota, termed "dysbiosis," often induce aberrant immune responses, which in turn disrupt the local and systemic homeostasis of the host. Emerging evidence has highlighted the importance of gut microbiota in intestinal diseases, and more recently, in age-related central nervous systems diseases, for example, stroke and Alzheimer's disease. It is now generally recognized that gut microbiota significantly influences host behaviors and modulates the interaction between microbiota, gut, and brain, via the "microbiota-gut-brain axis." Several approaches have been utilized to reduce age-related dysbiosis in experimental models and in clinical studies. These include strategies to manipulate the microbiome via fecal microbiota transplantation, administration of prebiotics and probiotics, and dietary interventions. In this review, we explore both clinical and preclinical therapies for treating age-related dysbiosis.

Indexed as

Gastrointestinal MicrobiomeAgingBrainDysbiosisFecal Microbiota TransplantationHumansNervous System Diseases

Identifiers

PMID32755639
PMCPMC7590960
OpenAlexW3046382238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.