ArticleCell reports2020
RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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25citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Article
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- The Adiponectin-PP2A Pathway Confers Cognitive Benefits of Physical Exercise Against Chronic Stress-Induced Tau Hyperphosphorylation in the Hippocampus.Aging cell · 2026Article
- Mechanisms of exercise against anxiety disorder: A review of the research progress.Sports medicine and health science · 2026Review
- FMRP regulation of STAT3-MYC signaling is critical for adult hippocampal neurogenesis and cognitive flexibility.Cell death and differentiation · 2026Article
- Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex.Neuron · 2025Article
- Nuclear magnetic resonance-based metabolomic study of rat brain after different intensity treadmill running.Journal of physiology and biochemistry · 2025Article
- Molecular signatures of regional vulnerability to tauopathy in excitatory cortical neurons.Acta neuropathologica · 2025Article
- Hippocampal Neurogenesis via Light-Intensity Running and Its Mechanism.Advances in neurobiology · 2025Review
- Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics.Progress in neurobiology · 2024Article
- Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus.Science advances · 2024Article
- 3D bioprinting of human neural tissues with functional connectivity.Cell stem cell · 2024Article
- The missing hallmark of health: psychosocial adaptation.Cell stress · 2024Article
- Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.Neuron · 2023Article
- Neural stem cells persist to generate new neurons in the hippocampus of adult and aged human brain - Fiction or accurate?Ageing research reviews · 2023Review
- Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway.Nature communications · 2023Article
- Exercise Promotes Tissue Regeneration: Mechanisms Involved and Therapeutic Scope.Sports medicine - open · 2023Review
- Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis.Hippocampus · 2023Review
- Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome.BMC medicine · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 2 institutions in 1 country.
Yu GaoWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Minjie ShenWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Jose Carlos GonzalezDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Qiping DongWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Sudharsan KannanWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Johnson T HoangWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Brian E EisingerWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Jyotsna PandeyWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Sahar JavadiWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Qiang ChangWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Daifeng WangWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Linda Overstreet-WadicheDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Xinyu ZhaoWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: xinyu.zhao@wisc.edu.
University of Wisconsin–Madison · USUniversity of Alabama at Birmingham · US
Funding
Understanding the molecular mechanisms that contribute to neuropsychiatric symptoms in Alzheimer DiseaseR01AG067025 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FINKBEINER, STEVEN M, HAROUTUNIAN, VAHRAM · 2019 to 2023
$11.8MDiscovery and validation of neuronal enhancers as development of psychiatric disorders supplementU01MH116492 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GERSTEIN, MARK BENDER, WENG, ZHIPING · 2018 to 2023
$6.2MWaisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI CHANG, QIANG · 2016 to 2020
$6.0MNewborn Neurons in the Adult Hippocampal NetworkR01NS064025 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2009 to 2023
$5.6MIn Vivo Function of Neuronal Activity-Induced MeCP2 phosphorylationR01HD064743 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI CHANG, QIANG · 2010 to 2021
$3.0MThe Role of MDM2 in FMRP regulation of neuronal developmentR01MH116582 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2018 to 2022
$2.2MThe role of RNA binding protein in FXR1P in interneuronsR01MH118827 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2019 to 2023
$2.2MInhibitory Neural Circuits in Dentate FunctionR01NS105438 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2018 to 2022
$2.1MIntegration of Experience-Induced Gene Expression and Circuit FunctionsR01NS105200 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI JACKSON, MEYER B., ZHAO, XINYU · 2018 to 2022
$2.0MCoordinate actions between methyl-CpG binding proteins in neuronal developmentR21NS095632 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2015 to 2016
$418kCircuit Activity and Synaptic Integration of Newborn Neurons in the Dentate GyrusR21NS098767 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI JACKSON, MEYER B., ZHAO, XINYU · 2017 to 2018
$408kEpigenetic Crosstalk Regulates Neuronal DevelopmentR56MH113146 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2017 to 2017
$383kNIA NIH HHS R01 AG067025NICHD NIH HHS R01 HD064743NICHD NIH HHS U54 HD090256NIMH NIH HHS R01 MH116582NIMH NIH HHS R01 MH118827NIMH NIH HHS R56 MH113146NIMH NIH HHS U01 MH116492NINDS NIH HHS R01 NS064025NINDS NIH HHS R01 NS105200NINDS NIH HHS R01 NS105438NINDS NIH HHS R21 NS095632NINDS NIH HHS R21 NS098767
Abstract
Voluntary running enhances adult hippocampal neurogenesis, with consequences for hippocampal-dependent learning ability and mood regulation. However, the underlying mechanism remains unclear. Here, we show that voluntary running induces unique and dynamic gene expression changes specifically within the adult-born hippocampal neurons, with significant impact on genes involved in neuronal maturation and human diseases. We identify the regulator of G protein signaling 6 (RGS6) as a key factor that mediates running impact on adult-born neurons. RGS6 overexpression mimics the positive effects of voluntary running on morphological and physiological maturation of adult new neurons and reduced sensitivity of adult-born neurons to the inhibitory effect of GABA
Indexed as
NeurogenesisPhysical Conditioning, AnimalAgingAnimalsAnxietyCell DifferentiationGene Expression RegulationHippocampusHumansMemoryMice, Inbred C57BLNeuronsReceptors, GABA-BRGS ProteinsReceptors, GABA-BRgs6 protein, mouseRGS Proteinsadult neurogenesisanxietyGABAgene expressionhippocampuslearningneuronal maturationRgs6RiboTag-seqvoluntary running
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.