Evidence map›Paper›PMID 32755457›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

DNGR1-Cre-mediated Deletion of

Thomas Koudstaal, Jennifer A C van Hulst, Tridib Das, Stefan F H Neys, Daphne Merkus, Ingrid M Bergen, Michiel A de Raaf, Harm Jan Bogaard, Louis Boon, Geert van Loo and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Frontiers in immunology · 2026
    Article
  3. Article
  4. Review
  5. Vascular Remodeling: The Multicellular Mechanisms of Pulmonary Hypertension.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Dissecting the lung transcriptome of pulmonary fibrosis-associated pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  11. Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  12. Review
  13. Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy.American journal of respiratory and critical care medicine · 2024
    Article
  14. Pulmonary Hypertension: A Contemporary Review.American journal of respiratory and critical care medicine · 2023
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Thomas KoudstaalDepartment of Pulmonary Medicine.ORCID 0000-0002-7655-4830
Jennifer A C van HulstDepartment of Pulmonary Medicine.
Tridib DasDepartment of Pulmonary Medicine.
Stefan F H NeysDepartment of Pulmonary Medicine.
Daphne MerkusDepartment of Cardiology, and.ORCID 0000-0002-4852-831X
Ingrid M BergenDepartment of Pulmonary Medicine.
Michiel A de RaafDepartment of Neonatology, Erasmus Medical Centre, Rotterdam, the Netherlands.
Harm Jan BogaardVU Medical Centre, Amsterdam, the Netherlands.
Louis BoonPolpharma Biologics, Utrecht, the Netherlands.
Geert van LooVIB Center for Inflammation Research, Ghent, Belgium; and.
Joachim G J V AertsDepartment of Pulmonary Medicine.
Karin A BoomarsDepartment of Pulmonary Medicine.
Mirjam KoolDepartment of Pulmonary Medicine.
Rudi W HendriksDepartment of Pulmonary Medicine.
Pulmonary Associates · USAmsterdam UMC Location Vrije Universiteit Amsterdam · NLGhent University · BEPolpharma Biologics (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic perivascular inflammation is a prominent feature in the lungs of idiopathic pulmonary arterial hypertension. Although the proportions of conventional dendritic cells (cDCs) and plasmacytoid DCs are increased in idiopathic pulmonary arterial hypertension lungs, it remains unknown whether activated cDCs play a pathogenic role. The

Indexed as

Gene DeletionAnimalsAutoantibodiesB-LymphocytesCytokinesDendritic CellsFemaleHypertension, PulmonaryImmunoglobulin AIntegrasesLectins, C-TypeLungLymphocyte ActivationMaleMice, Inbred C57BLMice, KnockoutAutoantibodiesClec9a protein, mouseCre recombinaseCytokinesImmunoglobulin AIntegrasesLectins, C-TypeReceptors, ImmunologicTnfaip3 protein, mouseTumor Necrosis Factor alpha-Induced Protein 3dendritic cellsinflammation and immunitypulmonary hypertensionpulmonary vascular remodeling

Identifiers

PMID32755457
OpenAlexW3047425902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.