Evidence map›Paper›PMID 32755358›Full record

SynthesisCritical reviews in toxicology2020

A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent.

David A Jett, Christopher A Sibrizzi, Robyn B Blain, Pamela A Hartman, Pamela J Lein, Kyla W Taylor, Andrew A Rooney

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical reviews in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

David A JettNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Christopher A SibrizziICF, Fairfax, VA, USA.
Robyn B BlainICF, Fairfax, VA, USA.
Pamela A HartmanICF, Fairfax, VA, USA.
Pamela J LeinSchool of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
Kyla W TaylorDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, NC, USA.
Andrew A RooneyDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, NC, USA.
ICF International (United States) · USNational Institute of Environmental Health Sciences · USNational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USUniversity of California, Davis · US

Funding

Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

Sarin is a highly toxic nerve agent that was developed for chemical warfare during World War II and is used in present conflicts. Immediate effects of acute sarin exposure are established; however, whether effects persist after initial signs have subsided is debated. The National Toxicology Program (NTP) conducted a systematic review to evaluate the evidence for long-term neurological effects following acute (<24 hour) exposure to sarin. The literature search and screening process identified 32 data sets within the 34 human studies and 47 data sets within the 51 animal studies (from 6837 potentially relevant references) that met the objective and the inclusion criteria. Four main health effect categories of neurological response were identified as having sufficient data to reach hazard conclusions: (1) cholinesterase levels; (2) visual and ocular effects; (3) effects on learning, memory, and intelligence; and (4) morphology and histopathology in nervous system tissues. NTP concluded that acute sarin exposure is

Indexed as

Nerve AgentsSarinChemical Warfare AgentsEnvironmental ExposureHumansTimeChemical Warfare AgentsNerve AgentsSarinchemical weaponlong-term effectsNational Toxicology Programnerve agentSarin

Identifiers

PMID32755358
PMCPMC8011809
OpenAlexW3046941434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.