ArticleStroke2020
Clinical Course and Mortality of Stroke Patients With Coronavirus Disease 2019 in Wuhan, China.
Article in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: incidence, risk factors, and pathogenesis - a systematic review and meta-analysis.F1000Research · 2021Pooled it
- Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters.BMC neuroscience · 2024Article
- Susceptibility of Fat Tissue to SARS-CoV-2 Infection in Female hACE2 Mouse Model.International journal of molecular sciences · 2023Article
- Review
- What is the impact of previous cerebrovascular disease on critical COVID-19 patients' mortality? A prospective cohort study.Journal of the neurological sciences · 2022Article
- Review
- Heterogeneity and Risk of Bias in Studies Examining Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2022Review
- Early Stroke Prediction Methods for Prevention of Strokes.Behavioural neurology · 2022Article
- Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action.EClinicalMedicine · 2021Article
- Temporal trend of comorbidity and increasing impacts on mortality, length of stay, and hospital costs of first stroke in Tianjin, North of China.Cost effectiveness and resource allocation : C/E · 2021Article
- Mortality rate and biomarker expression within COVID-19 patients who develop acute ischemic stroke: a systematic review and meta-analysis.Future science OA · 2021Review
- Deep Learning-Based Stroke Disease Prediction System Using Real-Time Bio Signals.Sensors (Basel, Switzerland) · 2021Article
- Review
- Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19.Journal of clinical medicine · 2021Article
- Predicting COVID-19 Severity with a Specific Nucleocapsid Antibody plus Disease Risk Factor Score.mSphere · 2021Article
- COVID-19: Neuroimaging Features of a Pandemic.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Review
- Article
- Eosinophil: A Nonnegligible Predictor in COVID-19 Re-Positive Patients.Frontiers in immunology · 2021Article
- COVID-19: patients with stroke or risk of stroke.European heart journal supplements : journal of the European Society of Cardiology · 2020Article
- COVID-19 and cerebrovascular diseases: a comprehensive overview.Therapeutic advances in neurological disorders · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeNo studies have reported the effect of the coronavirus disease 2019 (COVID-19) epidemic on patients with preexisting stroke. We aim to study the clinical course of COVID-19 patients with preexisting stroke and to investigate death-related risk factors.
methodsWe consecutively included 651 adult inpatients with COVID-19 from the Central Hospital of Wuhan between January 2 and February 15, 2020. Data on the demography, comorbidities, clinical manifestations, laboratory findings, treatments, complications, and outcomes (ie, discharged or death) of the participants were extracted from electronic medical records and compared between patients with and without preexisting stroke. The association between risk factors and mortality was estimated using a Cox proportional hazards regression model for stroke patients infected with severe acute respiratory syndrome coronavirus 2.
resultsOf the 651 patients with COVID-19, 49 with preexisting stroke tended to be elderly, male, had more underlying comorbidities and greater severity of illness, prolonged length of hospital stay, and greater hospitalization expenses than those without preexisting stroke. Cox regression analysis indicated that the patients with stroke had a higher risk of developing critical pneumonia (adjusted hazard ratio, 2.01 [95% CI, 1.27-3.16]) and subsequent mortality (adjusted hazard ratio, 1.73 [95% CI, 1.00-2.98]) than the patients without stroke. Among the 49 stroke patients, older age and higher score of Glasgow Coma Scale or Sequential Organ Failure Assessment were independent risk factors associated with in-hospital mortality.
conclusionsPreexisting stroke patients infected with severe acute respiratory syndrome coronavirus 2 were readily predisposed to death, providing an important message to individuals and health care workers that preventive measures must be implemented to protect and reduce transmission in stroke patients in this COVID-19 crisis.
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