Evidence map›Paper›PMID 32755339›Full record

ArticleJournal of neurophysiology2020

Enabling respiratory control after severe chronic tetraplegia: an exploratory case study.

Parag Gad, Evgeniy Kreydin, Hui Zhong, V Reggie Edgerton

Abstract readCase Reports
In one paragraph

Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  15. Regulation of Human Respiration by Electrical Stimulation.Journal of evolutionary biochemistry and physiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Parag GadDepartment of Neurobiology, University of California, Los Angeles, California.
Evgeniy KreydinDepartment of Urology, Keck School of Medicine of University of Southern California, Los Angeles, California.
Hui ZhongDepartment of Neurobiology, University of California, Los Angeles, California.
V Reggie EdgertonDepartment of Neurobiology, University of California, Los Angeles, California.

Funding

Structural and functional mapping of visceral pain afferent neurocircuitries of the colorectum and bladder in preclinical modelsU01NS113871 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MULUGETA, MILLION · 2019 to 2021
$2.1M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1U01NS113871-01NINDS NIH HHS U01 NS113871
6 · The paper itself

Abstract

Respiratory dysfunction is one of the most debilitating effects of spinal cord injury (SCI) impacting the quality of life of patients and caregivers. In addition, breathing difficulties impact the rehabilitation routine a patient may potentially undergo. Transcutaneous electrical spinal cord neuromodulation (TESCoN) is a novel approach to reactivate and retrain spinal circuits after paralysis. We demonstrate that acute and chronic TESCoN therapy over the cervical spinal cord positively impacts the breathing and coughing ability in a patient with chronic tetraplegia. ln addition, we show that the improved breathing and coughing ability are not only observed in the presence of TESCoN but persisted for a few days after TESCoN was stopped.

Indexed as

CoughSpinal Cord StimulationAdultCervical CordChronic DiseaseHumansMaleQuadriplegiaRespiration Disordersbreathingcoughingnoninvasive spinal cord stimulationspinal cord injury

Identifiers

PMID32755339
PMCPMC7509292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.