ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020
The potential role of the carotid body in COVID-19.
Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- The potential role of carvedilol in COVID-19 management: perspective and take-away.Inflammopharmacology · 2025Review
- Carotid Body Size on CT Angiography in Patients With COVID-19 Pneumonia.British journal of biomedical science · 2025Article
- Post-COVID breathlessness: a mathematical model of respiratory processing in the brain.European archives of psychiatry and clinical neuroscience · 2024Article
- COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator.Biological cybernetics · 2024Article
- ACE2 Receptor and TMPRSS2 Protein Expression Patterns in the Human Brainstem Reveal Anatomical Regions Potentially Vulnerable to SARS-CoV-2 Infection.ACS chemical neuroscience · 2023Article
- Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei.NPJ Parkinson's disease · 2023Article
- SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System.Neuroscience insights · 2023Article
- COVID-19 Smell Impairment and Crosstalk with Hypoxia Physiology.Life (Basel, Switzerland) · 2022Article
- Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation.Peptides · 2022Review
- Day-to-day blood pressure variability in COVID-19: A biomarker of disrupted central autonomic network.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Multiple Aspects of Inappropriate Action of Renin-Angiotensin, Vasopressin, and Oxytocin Systems in Neuropsychiatric and Neurodegenerative Diseases.Journal of clinical medicine · 2022Review
- Are Multiple Chemosensory Systems Accountable for COVID-19 Outcome?Journal of clinical medicine · 2021Review
- Silent hypoxia in COVID-19: a gut microbiota connection.Current opinion in physiology · 2021Review
- Early Detection of Symptom Exacerbation in Patients With SARS-CoV-2 Infection Using the Fitbit Charge 3 (DEXTERITY): Pilot Evaluation.JMIR formative research · 2021Article
- Day-to-day blood pressure variability and severity of COVID-19: Is sympathetic overdrive a potential link?Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Relevance of carotid bodies in COVID-19: A hypothetical viewpoint.Autonomic neuroscience : basic & clinical · 2021Review
- Effects of β-Blockers on the Sympathetic and Cytokines Storms in Covid-19.Frontiers in immunology · 2021Review
- Case Report: The Carotid Body in COVID-19: Histopathological and Virological Analyses of an Autopsy Case Series.Frontiers in immunology · 2021Article
- Possible Role of Corollary Discharge in Lack of Dyspnea in Patients With COVID-19 Disease.Frontiers in physiology · 2021Article
- 3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone.Frontiers in neuroanatomy · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The carotid body (CB) plays a contributory role in the pathogenesis of various respiratory, cardiovascular, renal, and metabolic diseases through reflex changes in ventilation and sympathetic output. On the basis of available data about peripheral arterial chemoreception and severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), a potential involvement in the coronavirus disease 2019 (COVID-19) may be hypothesized through different mechanisms. The CB could be a site of SARS-CoV-2 invasion, due to local expression of its receptor [angiotensin-converting enzyme (ACE) 2] and an alternative route of nervous system invasion, through retrograde transport along the carotid sinus nerve. The CB function could be affected by COVID-19-induced inflammatory/immune reactions and/or ACE1/ACE2 imbalance, both at local or systemic level. Increased peripheral arterial chemosensitivity and reflex sympatho-activation may contribute to the increased morbidity and mortality in COVID-19 patients with respiratory, cardiovascular, renal, or metabolic comorbidities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.