Evidence map›Paper›PMID 32755324›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.

Craig A Gelfand, Reiko Sakurai, Ying Wang, Yitian Liu, Robert Segal, Virender K Rehan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

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  10. Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Craig A GelfandAdvent Therapeutics, Inc., Doylestown, Pennsylvania.
Reiko SakuraiDepartment of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, David Geffen School of Medicine, Torrance, California.
Ying WangDepartment of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, David Geffen School of Medicine, Torrance, California.
Yitian LiuDepartment of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, David Geffen School of Medicine, Torrance, California.
Robert SegalAdvent Therapeutics, Inc., Doylestown, Pennsylvania.
Virender K RehanDepartment of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, David Geffen School of Medicine, Torrance, California.
Harbor–UCLA Medical Center · USDoylestown Hospital · USUCLA Medical Center · US

Funding

Aerosolized Vitamin A: Impact on Neonatal Lung Maturation, Hyperoxic Lung Injury and Bronchopulmonary DysplasiaR44HL142353 · NHLBI · ADVENT THERAPEUTICS, INC. · PI GELFAND, CRAIG, REHAN, VIRENDER K · 2020 to 2025
$5.3M
E-Cigarette Vaping during Pregnancy and Lactation, Germ Cell Epigenetic Memory, and Transgenerational AsthmaR01HL151769 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ALLARD, PATRICK, REHAN, VIRENDER K · 2020 to 2023
$2.3M
Developmental Nicotine Exposure & Transgenerationally Altered Lung PhenotypeR01HL127237 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2016 to 2019
$1.8M
In Utero Nicotine Exposure & Transgenerational Transmission of AsthmaR21HD071731 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2012 to 2013
$369k
Aerosolized vitamin A impact on lung maturation and hyperoxic neonatal lung injuryR43HL142353 · NHLBI · ADVENT THERAPEUTICS, INC. · PI GELFAND, CRAIG, REHAN, VIRENDER K · 2018 to 2018
$225k
HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) HL127137HHS | NIH | National Institute of Child Health and Human Development (NICHD) HD071731NCIRD CDC HHS K01 IP000050NHLBI NIH HHS R01 HL127237NHLBI NIH HHS R01 HL151769NHLBI NIH HHS R43 HL142353NHLBI NIH HHS R44 HL142353NICHD NIH HHS R21 HD071731
6 · The paper itself

Abstract

Prevention of bronchopulmonary dysplasia (BPD) in premature-birth babies continues to be an unmet medical need. Intramuscular vitamin A is currently employed in preterm neonates to prevent BPD but requires intramuscular injections in fragile neonates. We hypothesized that noninvasive inhaled delivery of vitamin A, targeted to lung, would be a more effective and tolerable strategy. We employed our well-established hyperoxia-injury neonatal rat model, exposing newborn rats to 7 days of constant extreme (95% O

Indexed as

Acute Lung InjuryAnimalsAnimals, NewbornBronchopulmonary DysplasiaHyperoxiaLungPulmonary AlveoliPulmonary SurfactantsRatsVitamin APulmonary SurfactantsVitamin Achronic lung disease of prematurityinhalation dosinglung injury repairpreterm birthvitamin a palmitate

Identifiers

PMID32755324
PMCPMC7642870
OpenAlexW3047132547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.