Evidence map›Paper›PMID 32755258›Full record

ArticleDrug delivery2020

Sustained delivery of 17β-estradiol by human amniotic extracellular matrix (HAECM) scaffold integrated with PLGA microspheres for endometrium regeneration.

Yue Chen, Weidong Fei, Yunchun Zhao, Fengmei Wang, Xiaoling Zheng, Xiaofei Luan, Caihong Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  8. Advances in using biomaterials for repairing thin endometrium.Frontiers in bioengineering and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yue ChenDepartment of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Weidong FeiDepartment of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yunchun ZhaoDepartment of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0001-6026-5869
Fengmei WangDepartment of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xiaoling ZhengDepartment of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xiaofei LuanDepartment of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Caihong ZhengDepartment of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Women's Hospital, School of Medicine, Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endometrial injury usually results in intrauterine adhesions (IUAs). However, there is no effective treatment to promote the regeneration of the endometrium currently. The decellularized amnion membrane (AM) is a promising material in human tissue repair and regeneration due to its biocompatibility, biodegradability, as well as the preservation of abundant bioactive components. Here, an innovative drug-delivering system based on human amniotic extracellular matrix (HAECM) scaffolds were developed to facilitate endometrium regeneration. The 17β-estradiol (E

Indexed as

MicrospheresAmnionCells, CulturedDelayed-Action PreparationsDose-Response Relationship, DrugDrug Delivery SystemsDrug LiberationEndometriumEstradiolEstrogensExtracellular MatrixFemaleHumansPolylactic Acid-Polyglycolic Acid CopolymerRegenerationRheologyDelayed-Action PreparationsEstradiolEstrogensPolylactic Acid-Polyglycolic Acid Copolymerbiologic scaffoldsendometrium regenerationHuman amniotic extracellular matrixPLGA microspheres

Identifiers

PMID32755258
PMCPMC7470125
OpenAlexW3047128469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.