Evidence map›Paper›PMID 32755037›Full record

ArticleJournal of cellular and molecular medicine2020

Honokiol ameliorates angiotensin II-induced hypertension and endothelial dysfunction by inhibiting HDAC6-mediated cystathionine γ-lyase degradation.

Zhexi Chi, Truc Phan Hoang Le, Sang Ki Lee, Erling Guo, Dongsoo Kim, Sanha Lee, Seung-Yong Seo, Sook Young Lee, Jae Hyung Kim, Sang Yoon Lee

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. A Paradigm Shift of HCurrent issues in molecular biology · 2026
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  8. Posttranslational Regulation of Mammalian Sulfur Amino Acid Metabolism.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Zhexi ChiDepartment of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.
Truc Phan Hoang LeDepartment of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.
Sang Ki LeeDepartment of Sport Science, Chungnam National University, Daejeon, Korea.
Erling GuoDepartment of Sport Science, Chungnam National University, Daejeon, Korea.
Dongsoo KimDepartment of Anesthesiology and Pain Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
Sanha LeeCollege of Pharmacy, Gachon University, Incheon, Korea.
Seung-Yong SeoCollege of Pharmacy, Gachon University, Incheon, Korea.
Sook Young LeeDepartment of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.
Jae Hyung KimDepartment of Anesthesiology and Pain Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
Sang Yoon LeeDepartment of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.ORCID 0000-0003-4695-0266
Gachon University · KRAjou University · KRChungnam National University · KRHallym University Dongtan Sacred Heart Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension and endothelial dysfunction are associated with various cardiovascular diseases. Hydrogen sulphide (H

Indexed as

AcetylationAllyl CompoundsAngiotensin IIAnimalsAortaBiphenyl CompoundsCystathionine gamma-LyaseEndothelial CellsHEK293 CellsHistone Deacetylase 6HumansHydrogen SulfideHypertensionLignansMaleMiceAllyl CompoundsAngiotensin IIBiphenyl CompoundsCystathionine gamma-LyaseHDAC6 protein, humanHdac6 protein, mouseHistone Deacetylase 6honokiolHydrogen SulfideLignansPhenolsProteasome Endopeptidase ComplexRecombinant Proteinsacetylationangiotensin IIcystathionine γ-lyasehistone deacetylase 6honokiolhydrogen sulphidehypertension

Identifiers

PMID32755037
PMCPMC7521302
OpenAlexW3046997450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.