ArticleDevelopmental psychobiology2021
Material hardship, prefrontal cortex-amygdala structure, and internalizing symptoms in children.
Article in Developmental psychobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Cumulative childhood lead exposure estimation and school-age IQ in a prospective birth cohort.Environmental health : a global access science source · 2025Article
- Association Between Neighborhood Opportunity, Cognitive Function, and Brain Structure in Youths.Biological psychiatry global open science · 2025Article
- Smaller Subcortical Volume in Reward Processing Regions Precedes Weight Gain in Youth With High Financial Adversity: Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
- Socioeconomic Disparities in Hypothalamic-Pituitary-Adrenal Axis Regulation and Prefrontal Cortical Structure.Biological psychiatry global open science · 2024Review
- Early life stress, prenatal secondhand smoke exposure, and the development of internalizing symptoms across childhood.Environmental health : a global access science source · 2023Article
- Profiles of Early Childhood Adversity in an Urban Pediatric Clinic: Implications for Pediatric Primary Care.Children (Basel, Switzerland) · 2023Article
- Differential Developmental Associations of Material Hardship Exposure and Adolescent Amygdala-Prefrontal Cortex White Matter Connectivity.Journal of cognitive neuroscience · 2022Article
- Assessment of Parent Income and Education, Neighborhood Disadvantage, and Child Brain Structure.JAMA network open · 2022Article
- Socioeconomic factors, stress, hair cortisol, and white matter microstructure in children.Developmental psychobiology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Material hardship, or difficulty affording basic resources such as food, housing, utilities, and health care, increases children's risk for internalizing problems. The uncinate fasciculus (UNC) and two of the gray matter regions it connects-the orbitofrontal cortex (OFC) and amygdala-may play important roles in the neural mechanisms underlying these associations. We investigated associations among material hardship, UNC microstructure, OFC and amygdala structure, and internalizing symptoms in children. Participants were 5-9-year-old children (N = 94, 61% female) from socioeconomically diverse families. Parents completed questionnaires assessing material hardship and children's internalizing symptoms. High-resolution, T1-weighted magnetic resonance imaging (n = 51), and diffusion tensor imaging (n = 58) data were acquired. UNC fractional anisotropy (FA), medial OFC surface area, and amygdala gray matter volume were extracted. Greater material hardship was significantly associated with lower UNC FA, smaller amygdala volume, and higher internalizing symptoms in children, after controlling for age, sex, and family income-to-needs ratio. Lower UNC FA significantly mediated the association between material hardship and internalizing symptoms in girls but not boys. These findings are consistent with the notion that material hardship may lead to altered white matter microstructure and gray matter structure in neural networks critical to emotion processing and regulation.
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Registered trials
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