Evidence map›Paper›PMID 32754844›Full record

ArticleSurgery today2021

Superiority of log odds of positive lymph nodes (LODDS) for prognostic prediction after gastric cancer surgery: a multi-institutional analysis of 7620 patients in China.

Pengfei Gu, Jingyu Deng, Zhe Sun, Zhenning Wang, Wei Wang, Han Liang, Huimian Xu, Zhiwei Zhou

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgery today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  3. Number of positive lymph nodes combined with the logarithmic ratio of positive lymph nodes predicts long-term survival for patients with node-positive parotid gland carcinoma after surgery: a SEER population-based study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Pengfei GuDepartment of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Cancer for Cancer, Tianjin, 300060, China.
Jingyu DengDepartment of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Cancer for Cancer, Tianjin, 300060, China. dengery@126.com.
Zhe SunDepartment of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Zhenning WangDepartment of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Wei WangDepartment of Gastric and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Han LiangDepartment of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Cancer for Cancer, Tianjin, 300060, China. xuhuimian@126.com.
Huimian XuDepartment of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China. tjlianghan@126.com.
Zhiwei ZhouDepartment of Gastric and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. zhouzhw@sysucc.org.cn.
Tianjin Medical University Cancer Institute and Hospital · CNChina Medical University · CNFirst Hospital of China Medical University · CNSun Yat-sen University · CNSun Yat-sen University Cancer Center · CN

Funding

National Key Research and Development Program MOST-2016YFC1303202National Precision Medicine Research Program 2017YFC0908304the National Key Clinical Specialist Construction Programs of China 2013-544the Programs of National Natural Science Foundation of China No. 81172080the Programs of National Natural Science Foundation of China No. 81201773the Programs of National Natural Science Foundation of China No. 81572372the Programs of National Natural Science Foundation of China No.81572372
6 · The paper itself

Abstract

purposeTo compare the 8th pN system with ratio-based and Log odds of positive lymph nodes (LODDS) staging systems for predicting the overall survival (OS) of gastric cancer (GC) patients after curative gastric resection.

methodsWe analyzed, retrospectively, clinicopathologic and prognostic data from three Chinese medical centers, on 7620 patients who underwent curative surgery for GC. We established a hypothetical tumor-LODDS-metastasis (TLM) and tumor-ratio-metastasis (TRM) staging system. The relative discriminative abilities of the different staging systems were assessed using Akaike's Information Criterion (AIC), a linear trend chi-square test, and a likelihood ratio chi-square test.

resultsThe cut-off points of the LODDS were set as: ≤ - 1.5, - 1.5 to - 1.0, - 1.0 to - 0.5, - 0.5 to 0, and > 0. There were significant differences in the survival of patients in different LODDS classifications for each pN or LNR group. When stratified by the LODDS classification, the prognosis was more homologous according to the pN or lymph-node ratio (LNR) classifications. The modified TLM staging system had better discriminatory ability and better optimistic prognostic stratification than the 8th TNM or the TRM staging systems for predicting the prognosis of patients with GC.

conclusionsThe LODDS staging system was superior to other lymph-node classifications for predicting the prognosis of patients undergoing gastrectomy GC. LODDS may be incorporated into a GC staging system if these results are confirmed by other studies.

Indexed as

GastrectomyAdenocarcinomaAdolescentAdultAgedAged, 80 and overChinaFemaleForecastingHumansLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm StagingPrognosisGastric cancerLODDSLymph node ratioLymph node stagePrognosis

Identifiers

PMID32754844
OpenAlexW3047328265

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.